Two new casbane diterpenoids from the roots of Euphorbia pekinensis

被引：35

作者：

Shao, Feng-Guang ^{[1
,2
]}

Bu, Ren ^{[2
]}

Zhang, Cui ^{[1
]}

Chen, Chao-Jun ^{[2
]}

Huang, Jian ^{[1
,3
]}

Wang, Jin-Hui ^{[1
,2
,3
,4
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med 49, Shenyang 110016, Peoples R China

[2] Inner Mongolia Med Coll, Sch Pharm, Hohhot 010110, Peoples R China

[3] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China

[4] Shihezi Univ, Sch Pharm, Shihezi 832002, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2011年 / 13卷 / 09期

关键词：

Euphorbia pekinensis Rupr; pekinenin A; pekinenin B; casbane diterpenoids; GENUS;

D O I：

10.1080/10286020.2011.596828

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From the roots of Euphorbia pekinensis, two new casbane diterpenoids, named pekinenins A (1) and B (2), were isolated. Their structures were elucidated as 18-hydroxy-1 beta H,2 alpha H-casba-3E,7E,11E-trien-5-one (1), 5 alpha-methoxy-1 beta H,2 alpha H-casba-3Z,7E,11E-trien-18-oic acid (2) by a combination of 1D and 2D NMR spectroscopy and mass spectrometry. In the cytotoxicity assay of the two new compounds against Hela, MCF-7, and C6 human cancer cell lines, compound 1 showed moderate cytotoxic activity against two human cancer cell lines, Hela and C6, with IC50 values of 42.97 and 50.00 mu M, respectively.

引用

页码：805 / 810

页数：6

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