SGLT-2 Inhibitors in Heart Failure and Type-2 Diabetes: Hitting Two Birds with One Stone?

被引：25

作者：

Santos-Ferreira, Diogo ^{[1
,2
]}

Goncalves-Teixeira, Pedro ^{[1
,2
]}

Fontes-Carvalho, Ricardo ^{[1
,2
]}

机构：

[1] Ctr Hosp Vila Nova de Gaia Espinho, Serv Cardiol, Porto, Portugal

[2] Univ Porto, Fac Med, Dept Cirurgia & Fisiol, Unidade Invest Cardiovasc, PT-4200319 Porto, Portugal

来源：

CARDIOLOGY | 2020年 / 145卷 / 05期

关键词：

Diabetes mellitus; Type 2 diabetes mellitus; Diabetic cardiomyopathies; Heart failure; Chronic heart failure; Preventive cardiology; Sodium-glucose transporter 2 inhibitors; GLUCOSE-LOWERING DRUGS; CARDIOVASCULAR MORTALITY; INSULIN-RESISTANCE; GLYCEMIC CONTROL; LOWER RISK; CVD-REAL; EMPAGLIFLOZIN; MELLITUS; HOSPITALIZATION; NEPHROPATHY;

D O I：

10.1159/000504694

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes mellitus (T2DM) and heart failure (HF) have a tremendous impact worldwide, markedly reducing life-expectancy and quality of life. It is now known that each disease represents a risk factor for the other. Moreover, when they are combined, the prognosis is significantly worse. Until recently, these pathologies have been managed independently. However, their treatment paradigm is rapidly changing, with recent cardiovascular outcome trials showing that sodium-glucose cotransporter-2 inhibitors (SGLT-2i) are effective in the management of both diseases. This article explores the interactions between T2DM and HF and the concept of diabetic cardiomyopathy and summarizes recent data regarding the effects of SGLT-2i on HF hospitalization and the proposed pathophysiological mechanisms involved.

引用

页码：311 / 320

页数：10

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