Systemic and Cellular Reflections on Ageing and the Circadian Oscillator - A Mini-Review

被引：28

作者：

Brown, Steven A. ^{[1
]}

Pagani, Lucia ^{[2
]}

Cajochen, Christian ^{[3
]}

Eckert, Anne ^{[2
]}

机构：

[1] Univ Zurich, Dept Pharmacol & Toxicol, CH-8057 Zurich, Switzerland

[2] Psychiat Univ Clin Basel, Neurobiol Lab Brain Aging & Mental Hlth, Basel, Switzerland

[3] Psychiat Univ Clin Basel, Ctr Chronobiol, Basel, Switzerland

来源：

GERONTOLOGY | 2011年 / 57卷 / 05期

关键词：

Circadian rhythm; Biological clock; Physiology; AGE-RELATED-CHANGES; SUPRACHIASMATIC NUCLEUS; GENE-EXPRESSION; BRIGHT LIGHT; NONPHARMACOLOGICAL INTERVENTION; HOMEOSTATIC REGULATION; BIOLOGICAL CLOCK; HUMAN SLEEP; RHYTHMS; MELATONIN;

D O I：

10.1159/000320673

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

From circulation to digestion to excretion, a circadian clock synchronizes most aspects of mammalian physiology with the solar day. During normal ageing, this daily coordination gradually erodes, and during pathological ageing such erosion is exacerbated. Recent experiments suggest that therapies aimed at sustaining circadian function increase quality of life in elderly patients. Hence, a better understanding of the interactions between the circadian clock and ageing - at both cellular and systemic levels - could lead to direct benefits for aged individuals. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：427 / 434

页数：8

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