Bioengineering Strategies to Create 3D Cardiac Constructs from Human Induced Pluripotent Stem Cells

被引：18

作者：

Varzideh, Fahimeh ^{[1
,2
]}

Mone, Pasquale ^{[1
]}

Santulli, Gaetano ^{[1
,2
]}

机构：

[1] Albert Einstein Coll Med, Dept Med, Wilf Family Cardiovasc Res Inst, Einstein Mt Sinai Diabet Res Ctr ES DRC,Einstein, New York, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Mol Pharmacol, Fleischer Inst Diabet & Metab FIDAM, Einstein Inst Neuroimmunol & Inflammat INI, New York, NY 10461 USA

来源：

BIOENGINEERING-BASEL | 2022年 / 9卷 / 04期

基金：

美国国家卫生研究院;

关键词：

3D bioprinting; 3D models; cardiac organoid; cardiac tissue engineering; cardiomyocytes; CPVT; differentiation; disease modeling; drug development; drug screening; ECM; heart-on-a-chip; hiPSC-CMs; human induced pluripotent stem cell; iPSC; Layer-by-Layer; maturation;

D O I：

10.3390/bioengineering9040168

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Human induced pluripotent stem cells (hiPSCs) can be used to generate various cell types in the human body. Hence, hiPSC-derived cardiomyocytes (hiPSC-CMs) represent a significant cell source for disease modeling, drug testing, and regenerative medicine. The immaturity of hiPSC-CMs in two-dimensional (2D) culture limit their applications. Cardiac tissue engineering provides a new promise for both basic and clinical research. Advanced bioengineered cardiac in vitro models can create contractile structures that serve as exquisite in vitro heart microtissues for drug testing and disease modeling, thereby promoting the identification of better treatments for cardiovascular disorders. In this review, we will introduce recent advances of bioengineering technologies to produce in vitro cardiac tissues derived from hiPSCs.

引用

页数：16

共 186 条

[1] Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling [J].

Abilez, Oscar J. ;

Tzatzalos, Evangeline ;

Yang, Huaxiao ;

Zhao, Ming-Tao ;

Jung, Gwanghyun ;

Zollner, Alexander M. ;

Tiburcy, Malte ;

Riegler, Johannes ;

Matsa, Elena ;

Shukla, Praveen ;

Yan Zhuge ;

Chour, Tony ;

Chen, Vincent C. ;

Burridge, Paul W. ;

Karakikes, Ioannis ;

Kuhl, Ellen ;

Bernstein, Daniel ;

Couture, Larry A. ;

Gold, Joseph D. ;

Zimmermann, Wolfram H. ;

Wu, Joseph C. .

STEM CELLS, 2018, 36 (02) :265-277

[2] Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function [J].

Abulaiti, Mosha ;

Yalikun, Yaxiaer ;

Murata, Kozue ;

Sato, Asako ;

Sami, Mustafa M. ;

Sasaki, Yuko ;

Fujiwara, Yasue ;

Minatoya, Kenji ;

Shiba, Yuji ;

Tanaka, Yo ;

Masumoto, Hidetoshi .

SCIENTIFIC REPORTS, 2020, 10 (01)

[3] A deep learning algorithm to translate and classify cardiac electrophysiology [J].

Aghasafari, Parya ;

Yang, Pei-Chi ;

Kernik, Divya C. ;

Sakamoto, Kazuho ;

Kanda, Yasunari ;

Kurokawa, Junko ;

Vorobyov, Igor ;

Clancy, Colleen E. .

ELIFE, 2021, 10

[4] Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery [J].

Ajalik, Raquel E. E. ;

Alenchery, Rahul G. G. ;

Cognetti, John S. S. ;

Zhang, Victor Z. Z. ;

McGrath, James L. L. ;

Miller, Benjamin L. L. ;

Awad, Hani A. A. .

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 10

[5] Layer-by-Layer Nanoparticles of Tamoxifen and Resveratrol for Dual Drug Delivery System and Potential Triple-Negative Breast Cancer Treatment [J].

Al-jubori, Ali A. ;

Sulaiman, Ghassan M. ;

Tawfeeq, Amer T. ;

Mohammed, Hamdoon A. ;

Khan, Riaz A. ;

Mohammed, Salman A. A. .

PHARMACEUTICS, 2021, 13 (07)

[6] Human Extracellular-Matrix Functionalization of 3D hiPSC-Based Cardiac Tissues Improves Cardiomyocyte Maturation [J].

Almeida, Henrique, V ;

Tenreiro, Miguel F. ;

Louro, Ana F. ;

Abecasis, Bernardo ;

Santinha, Deolinda ;

Calmeiro, Tomas ;

Fortunato, Elvira ;

Ferreira, Lino ;

Alves, Paula M. ;

Serra, Margarida .

ACS APPLIED BIO MATERIALS, 2021, 4 (02) :1888-1899

[7] Development of vascularized iPSC derived 3D-cardiomyocyte tissues by filtration Layer-by-Layer technique and their application for pharmaceutical assays [J].

Amano, Yuto ;

Nishiguchi, Akihiro ;

Matsusaki, Michiya ;

Iseoka, Hiroko ;

Miyagawa, Shigeru ;

Sawa, Yoshiki ;

Seo, Manabu ;

Yamaguchi, Takashi ;

Akashi, Mitsuru .

ACTA BIOMATERIALIA, 2016, 33 :110-121

[8] Precardiac organoids form two heart fields via Bmp/Wnt signaling [J].

Andersen, Peter ;

Tampakakis, Emmanouil ;

Jimenez, Dennisse V. ;

Kannan, Suraj ;

Miyamoto, Matthew ;

Shin, Hye Kyung ;

Saberi, Amir ;

Murphy, Sean ;

Sulistio, Edrick ;

Chelko, Stephen P. ;

Kwon, Chulan .

NATURE COMMUNICATIONS, 2018, 9

[9] Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research [J].

Andrysiak, Kalina ;

Stepniewski, Jacek ;

Dulak, Jozef .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2021, 473 (07) :1061-1085

[10] Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology [J].

Archer, Caroline R. ;

Sargeant, Rebecca ;

Basak, Jayati ;

Pilling, James ;

Barnes, Jennifer R. ;

Pointon, Amy .

SCIENTIFIC REPORTS, 2018, 8

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