One-Pot Synthesis of Benzo[f]indole-4,9-diones from 1,4-Naphthoquinones and Terminal Acetylenes

被引：0

作者：

Yamashita, Mitsuaki ^{[1
]}

Ueda, Kazunori ^{[2
]}

Sakaguchi, Koichi ^{[2
]}

Tokuda, Harukuni ^{[4
]}

Iida, Akira ^{[2
,3
]}

机构：

[1] Takasaki Univ Hlth & Welf, Fac Pharm, Nakaorui, Takasaki 3700033, Japan

[2] Kinki Univ, Sch Agr, Naka, Nara 6318505, Japan

[3] Res & Dev Ctr Med Plants, Kadoma, Kanazawa 9201164, Japan

[4] Kanazawa Univ, Dept Complementary & Alternat Med R&D, Grad Sch Med Sci, Takara, Kanazawa 9208640, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2011年 / 59卷 / 10期

关键词：

indolequinone; Sonogashira coupling; cascade reaction; copper; palladium; INDOLEQUINONE ANTITUMOR AGENTS; FREE-RADICAL REACTIONS; ANNULATION REACTION; COUPLING REACTIONS; DERIVATIVES; INDOLOQUINONES; CYTOTOXICITY; INDOLES; COPPER; EO9;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this paper, a concise one-pot method for the construction of benzo[f]indole-4,9-dione motifs is described. These transformations proceed via a sequential palladium- and copper-catalyzed coupling reaction of 1,4-naphthoquinones with terminal acetylenes, followed by a copper-catalyzed intramolecular cyclization reaction of the resulting coupling product.

引用

页码：1289 / 1293

页数：5

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