One-Pot Synthesis of Benzo[f]indole-4,9-diones from 1,4-Naphthoquinones and Terminal Acetylenes

被引：0
|
作者：
Yamashita, Mitsuaki [1 ]
Ueda, Kazunori [2 ]
Sakaguchi, Koichi [2 ]
Tokuda, Harukuni [4 ]
Iida, Akira [2 ,3 ]
机构：
[1] Takasaki Univ Hlth & Welf, Fac Pharm, Nakaorui, Takasaki 3700033, Japan
[2] Kinki Univ, Sch Agr, Naka, Nara 6318505, Japan
[3] Res & Dev Ctr Med Plants, Kadoma, Kanazawa 9201164, Japan
[4] Kanazawa Univ, Dept Complementary & Alternat Med R&D, Grad Sch Med Sci, Takara, Kanazawa 9208640, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2011年 / 59卷 / 10期
关键词：
indolequinone; Sonogashira coupling; cascade reaction; copper; palladium; INDOLEQUINONE ANTITUMOR AGENTS; FREE-RADICAL REACTIONS; ANNULATION REACTION; COUPLING REACTIONS; DERIVATIVES; INDOLOQUINONES; CYTOTOXICITY; INDOLES; COPPER; EO9;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this paper, a concise one-pot method for the construction of benzo[f]indole-4,9-dione motifs is described. These transformations proceed via a sequential palladium- and copper-catalyzed coupling reaction of 1,4-naphthoquinones with terminal acetylenes, followed by a copper-catalyzed intramolecular cyclization reaction of the resulting coupling product.
引用
收藏
页码：1289 / 1293
页数：5
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