RGDC Peptide Modified Quantum Dots Labelling and Imaging of Tumor Cells

被引：0

作者：

Guo Yi ^{[2
]}

Li Chun-rong ^{[2
]}

Shen Huai-bin ^{[1
]}

Zhang Xue-zhong ^{[2
]}

Li Lin-song ^{[1
]}

Yu Qian ^{[3
]}

Xu Li ^{[2
]}

机构：

[1] Henan Univ, Key Lab Special Funct Mat, Minist Educ, Kaifeng 475004, Peoples R China

[2] Jilin Univ, Coll Life Sci, Key Lab Mol Enzymol & Engn, Minist Educ, Changchun 130012, Peoples R China

[3] Jilin Univ, Dept Drug Adm, China Japan Union Hosp, Changchun 130033, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2011年 / 27卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Arginine-glycine-aspartic acid-cysteine(RGDC) peptide; Quantum dot; Fluorescence labelling; LIVING CELLS; LIVE CELLS; NANOCRYSTALS; TRACKING;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The labelling and imaging of tumor cells were investigated via arginine-glycine-aspartic acid-cysteine(RGDC) peptide-labelled quantum dots(QDs). The results show that RGDC modified QDs can label SMMC-7721 tumor cells and adhere to cellular membrane. In constrast, the unmodified QDs are mainly dispersed around the cell. We also found that the RGDC-QDs can penetrate into the cell at 2 h of incubation. After 6 h of incubation, RGDC-QDs can accumulate in a unique intracellular region.

引用

页码：832 / 835

页数：4

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