A positive feedback regulatory loop involving the lncRNA PVT1 and HIF-1α in pancreatic cancer

被引：19

作者：

Zhu, Yiping ^{[1
]}

Wu, Fang ^{[2
]}

Gui, Weiwei ^{[3
]}

Zhang, Nan ^{[2
]}

Matro, Erik ^{[3
]}

Zhu, Linghua ^{[1
]}

Eserberg, Daniel Turunen ^{[3
]}

Lin, Xihua ^{[2
,4
,5
]}

机构：

[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gen Surg, Hangzhou, Peoples R China

[2] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Endocrinol, Hangzhou, Peoples R China

[3] Zhejiang Univ, Sch Med, Hangzhou, Peoples R China

[4] Zhejiang Univ, Sir Run Run Shaw Hosp, Biomed Res Ctr, Hangzhou, Peoples R China

[5] Zhejiang Univ, Sir Run Run Shaw Hosp, Key Lab Biotherapy Zhejiang Prov, Hangzhou, Peoples R China

来源：

JOURNAL OF MOLECULAR CELL BIOLOGY | 2021年 / 13卷 / 09期

关键词：

PVT1; HIF-1; alpha; pancreatic cancer; feedforward regulatory loop; LONG NONCODING RNA; HYPOXIA-INDUCIBLE FACTORS; HYDROXYPROLINE; RECOGNITION; INVASION; REVEAL; IMPACT; GROWTH; MAPS;

D O I：

10.1093/jmcb/mjab042

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Extreme hypoxia is among the most prominent pathogenic features of pancreatic cancer (PC). Both the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) and hypoxic inducible factor-1 alpha (HIF-1 alpha) are highly expressed in PC patients and play a crucial role in disease progression. Reciprocal regulation involving PVT1 and HIF-1 alpha in PC, however, is poorly understood. Here, we report that PVT1 binds to the HIF-1 alpha promoter and activates its transcription. In addition, we found that PVT1 could bind to HIF-1 alpha and increases HIF-1 alpha post-translationally. Our findings suggest that the PVT1-HIF-1 alpha positive feedback loop is a potential therapeutic target in the treatment of PC.

引用

页码：676 / 689

页数：14

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