Effects of milnacipran, duloxetine and indomethacin, in polyarthritic rats using the Randall-Selitto model

被引:10
作者
Antonio Mico, Juan [2 ,3 ]
Berrocoso, Esther [2 ,3 ]
Vitton, Olivier [4 ]
Ladure, Philippe [5 ]
Newman-Tancredi, Adrian [6 ]
Bardin, Laurent
Depoortere, Ronan [1 ]
机构
[1] Ctr Rech Pierre Fabre, Div Neurobiol 2, F-81106 Castres, France
[2] Univ Cadiz, Fac Med, Dept Neurosci Pharmacol & Psychiat, Cadiz, Spain
[3] Inst Salud Carlos III, Ciber Mental Hlth CIBERSAM, Madrid, Spain
[4] Inst Rech Pierre Fabre Pierre Fabre Medicaments, Castres, France
[5] Inst Rech Pierre Fabre, Labege, France
[6] NeuroAct Commun, Castres, France
来源
BEHAVIOURAL PHARMACOLOGY | 2011年 / 22卷 / 5-6期
关键词
allodynia; arthritic pain; duloxetine; hyperalgesia; indomethacin; milnacipran; rat; ADJUVANT-INDUCED ARTHRITIS; PLACEBO-CONTROLLED TRIAL; SPINAL NERVE LIGATION; NEUROPATHIC PAIN; DOUBLE-BLIND; REUPTAKE INHIBITOR; RHEUMATOID-ARTHRITIS; MECHANICAL ALLODYNIA; VISCERAL DISTENSION; ANTIDEPRESSANTS;
D O I
10.1097/FBP.0b013e328345ca4e
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Milnacipran, a serotonin and noradrenalin reuptake inhibitor (SNRI), is efficacious in rodents in various models of acute or chronic pain (traumatic, neuropathic, inflammatory, visceral). However, its activity against arthritic pain has never been explored. Here, we assessed the activity of acute treatment with milnacipran in a polyarthritic rat model. Rats were injected in the tail base with complete Freund's adjuvant to induce a state of polyarthritis. Analgesic effects of acute treatment with intraperitoneal administration of milnacipran were then evaluated, using the Randall-Selitto model, against two levels of pressure applied to both hind paws (a lower one, addressing mechanical allodynia and a higher one, addressing mechanical hyperalgesia). The other SNRI duloxetine and the nonsteroidal anti-inflammatory drug indomethacin were tested as positive controls. Milnacipran was significantly and dose dependently active against the decrease of paw withdrawal threshold produced by complete Freund's adjuvant for low (minimum effective dose = 5 mg/kg, range tested: 2.5-10 mg/kg) and high (minimum effective dose = 10 mg/kg, range tested: 5-20 mg/kg)-pressure levels. Duloxetine (20 mg/kg, intraperitoneally) was significantly active against low pressure only. Indomethacin (3 mg/kg per os) was efficacious against both pressure levels. These rodent data suggest that milnacipran should be efficacious in painful conditions associated with chronic inflammatory states, such as arthritis. Behavioural Pharmacology 22: 599-606 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
引用
收藏
页码:599 / 606
页数:8
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