IMPACT OF AVERAGE WEEKLY DOSE OF RADIATION DURING RADIOTHERAPY ALONE OR CHEMORADIOTHERAPY IN HEAD AND NECK CANCER

被引：8

作者：

Dragovic, Aleksandar F. ^{[4
]}

Bonner, James A. ^{[4
]}

Spencer, Sharon A. ^{[4
]}

Nabell, Lisle M. ^{[1
]}

Carroll, William R. ^{[2
]}

Caudell, Jimmy J. ^{[3
,4
]}

机构：

[1] Univ Alabama Birmingham, Dept Internal Med, Birmingham, AL USA

[2] Univ Alabama Birmingham, Dept Surg, Birmingham, AL 35294 USA

[3] Univ Mississippi, Dept Radiat Oncol, Med Ctr, Mississippi, AL USA

[4] Univ Alabama Birmingham, Dept Radiat Oncol, Birmingham, AL 35294 USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2011年 / 33卷 / 11期

关键词：

head and neck cancer; radiotherapy; altered fractionation; chemotherapy; AWD; SQUAMOUS-CELL CARCINOMAS; LOCALLY ADVANCED HEAD; INTENSITY-MODULATED RADIOTHERAPY; ACCELERATED FRACTIONATION; LUNG-CARCINOMA; THERAPY; IRRADIATION; LARYNX; TRIAL;

D O I：

10.1002/hed.21634

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Altered fractionated radiotherapy (RT) has been shown to improve locoregional control (LRC) and overall survival (OS) in squamous cell cancer of the head and neck (SCCHN). We investigated patient outcomes using a new parameter: the average weekly dose (AWD). Methods. The medical records of 601 patients who received definitive RT for SCCHN were reviewed. AWD was calculated by dividing the total dose in Gray (Gy) by overall treatment time in weeks, and assessed for predictive value. Results. Various standard RT fractionation schedules were used. An AWD >10.0 Gy was associated with improved LRC at 2 years for patients treated with RT alone (80.9% vs 60.9%; p = .006), but not for those treated with concurrent chemoradiation (75.3% vs 77.3%; p = .77). Nonsignificant increases in late dysphagia were seen with AWD >10.0 Gy. Conclusion. An AWD of >10 Gy was found to be beneficial for RT alone regimens but not chemoradiotherapy regimens. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 1551-1556, 2011

引用

页码：1551 / 1556

页数：6

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