Nuclear Factor One X in Development and Disease

被引：43

作者：

Piper, Michael ^{[1
]}

Gronostajski, Richard ^{[2
]}

Messina, Graziella ^{[3
]}

机构：

[1] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia

[2] SUNY Buffalo, New York State Ctr Excellence Bioinformat & Life, Dept Biochem Genet, Genom & Bioinformat Grad Program, Buffalo, NY 14203 USA

[3] Univ Milan, Dept Biosci, Via Celoria 26, I-20133 Milan, Italy

来源：

TRENDS IN CELL BIOLOGY | 2019年 / 29卷 / 01期

基金：

澳大利亚研究理事会;

关键词：

FACTOR-I PROTEINS; MUSCULAR-DYSTROPHY; DNA-REPLICATION; TRANSCRIPTIONAL REGULATION; CELL-DIFFERENTIATION; EXPRESSION PATTERNS; DIVERGENT FUNCTIONS; CANCER PROGRESSION; HEMATOPOIETIC STEM; SPLICE VARIANTS;

D O I：

10.1016/j.tcb.2018.09.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The past decade has seen incredible advances in the field of stem cell biology that have greatly improved our understanding of development and provided important insights into pathological processes. Transcription factors (TFs) play a central role in mediating stem cell proliferation, quiescence, and differentiation. One TF that contributes to these processes is Nuclear Factor One X (NFIX). Recently, NFIX activity has been shown to be essential in multiple organ systems and to have important translational impacts for human health. Here, we describe recent studies showing the contribution of NFIX to muscle development and muscular dystrophies, hematopoiesis, cancer, and neural stem cell biology, highlighting the importance of this knowledge in the development of therapeutic targets.

引用

页码：20 / 30

页数：11

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