Assembly and disassembly of the ESCRT-III membrane scission complex

被引：66

作者：

Adell, Manuel Alonso Y. ^{[1
]}

Teis, David ^{[1
]}

机构：

[1] Med Univ Innsbruck, Div Cell Biol, A-6020 Innsbruck, Austria

来源：

FEBS LETTERS | 2011年 / 585卷 / 20期

基金：

奥地利科学基金会;

关键词：

ESCRT; Vps4; Multivesicular body (MVB); HIV; Cytokinesis; AAA-ATPASE VPS4; MULTIVESICULAR BODY BIOGENESIS; ENDOSOME-ASSOCIATED COMPLEX; STRUCTURAL BASIS; CELL-DIVISION; SORTING PATHWAY; PROTEIN; MACHINERY; FILAMENTS; CYTOKINESIS;

D O I：

10.1016/j.febslet.2011.09.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ESCRT (endosomal sorting complex required for transport) pathway promotes the final membrane scission step at the end of cytokinesis, assists viral budding and generates multivesicular bodies (MVBs). These seemingly unrelated processes require a topologically similar membrane deformation and scission event that buds membranes/vesicles out of the cytoplasm. The topology of this budding reaction is 'opposite' to reactions that bud endocytic and secretory vesicles into the cytoplasm. Here we summarize recent findings that help to understand how the ESCRT machinery, in particular the ESCRT-III complex, assembles on its target membranes, executes membrane scission and is disassembled by the AAA-ATPase Vps4. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3191 / 3196

页数：6

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