Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response

被引：63

作者：

Chan, Denise ^{[1
]}

Bennett, Phillip R. ^{[1
,2
]}

Lee, Yun S. ^{[1
,2
]}

Kundu, Samit ^{[1
,2
]}

Teoh, T. G. ^{[1
,2
,3
]}

Adan, Malko ^{[1
,2
]}

Ahmed, Saqa ^{[1
]}

Brown, Richard G. ^{[1
]}

David, Anna L. ^{[4
]}

Lewis, Holly, V ^{[1
]}

Gimeno-Molina, Belen ^{[1
,2
]}

Norman, Jane E. ^{[5
,6
]}

Stock, Sarah J. ^{[5
]}

Terzidou, Vasso ^{[1
,2
,7
]}

Kropf, Pascale ^{[2
,8
]}

Botto, Marina ^{[2
,9
]}

MacIntyre, David A. ^{[1
,2
]}

Sykes, Lynne ^{[1
,2
,3
]}

机构：

[1] Imperial Coll London, Imperial Coll Parturit Res Grp, Inst Reprod & Dev Biol, Dept Metab Digest & Reprod, London, England

[2] Imperial Coll London, March Dimes Prematur Res Ctr, London, England

[3] Imperial Coll Healthcare NHS Trust, St Marys Hosp, London, England

[4] UCL, Elizabeth Garrett Anderson Inst Womens Hlth, London, England

[5] Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland

[6] Univ Bristol, Fac Hlth Sci, Bristol, Avon, England

[7] Chelsea & Westminster Hosp, Imperial Coll Healthcare NHS Trust, London, England

[8] Imperial Coll London, Dept Infect Dis, London, England

[9] Imperial Coll London, Dept Immunol & Inflammat, London, England

来源：

NATURE COMMUNICATIONS | 2022年 / 13卷 / 01期

基金：

英国惠康基金;

关键词：

MANNOSE-BINDING LECTIN; COMPLEMENT ACTIVATION; VAGINAL MICROBIOME; CERVICAL-MUCUS; BIRTH; HEALTH; CELLS; WOMEN; FLUID;

D O I：

10.1038/s41467-022-28620-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There has been a surge in studies implicating a role of vaginal microbiota in spontaneous preterm birth (sPTB), but most are associative without mechanistic insight. Here we show a comprehensive approach to understand the causative factors of preterm birth, based on the integration of longitudinal vaginal microbiota and cervicovaginal fluid (CVF) immunophenotype data collected from 133 women at high-risk of sPTB. We show that vaginal depletion of Lactobacillus species and high bacterial diversity leads to increased mannose binding lectin (MBL), IgM, IgG, C3b, C5, IL-8, IL-6 and IL-1 beta and to increased risk of sPTB. Cervical shortening, which often precedes preterm birth, is associated with Lactobacillus iners and elevated levels of IgM, C3b, C5, C5a and IL-6. These data demonstrate a role for the complement system in microbial-driven sPTB and provide a scientific rationale for the development of live biotherapeutics and complement therapeutics to prevent sPTB. Gaining mechanistic insight into the microbiological and immunological factors that are associated with spontaneous preterm birth is important for the development of prevention strategies. Here authors show that the complement system in conjunction with specific vaginal microbial and associated immunological changes are contributing to this condition.

引用

页数：15

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