Breaking the Impasse Advances in Treatment of Small Cell Lung Cancer

被引：8

作者：

Saltos, Andreas ^{[1
]}

Antonia, Scott ^{[2
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Thorac Oncol, 12902 Magnolia Dr, Tampa, FL 33612 USA

[2] Duke Canc Inst, Ctr Canc Immunotherapy, 20 Duke Med Circle, Durham, NC 27710 USA

来源：

CLINICS IN CHEST MEDICINE | 2020年 / 41卷 / 02期

关键词：

Small cell lung cancer; Immunotherapy; DNA damage repair; DLL-3; PROPHYLACTIC CRANIAL IRRADIATION; PLATINUM-BASED CHEMOTHERAPY; PHASE-III TRIAL; THORACIC RADIOTHERAPY; OPEN-LABEL; ROVALPITUZUMAB TESIRINE; DOUBLE-BLIND; STAGE; IPILIMUMAB; COMBINATION;

D O I：

10.1016/j.ccm.2020.02.011

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Small cell lung cancer (SCLC) is an aggressive malignancy and carries a poor prognosis with limited effective treatments in the advanced setting. SCLC is characterized by a high tumor mutation burden and alterations in Notch signaling and DNA damage repair pathways, providing rationale for the use of immunotherapy and targeted therapies. Immunotherapies have led to the most significant advances in treating SCLC in decades, and several promising targeted approaches have emerged from the increased understanding of the biology of SCLC. However, responses to these novel approaches are far from universal, and efforts to refine these therapies are ongoing.

引用

页码：269 / +

页数：13

共 72 条

[1] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[2]

[Anonymous], 2019, 2019 WORLD C LUNG CA

[3]

[Anonymous], 2019, J CLIN ONCOL S

[4] Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial [J].

Antonia, Scott J. ;

Lopez-Martin, Jose A. ;

Bendell, Johanna ;

Ott, Patrick A. ;

Taylor, Matthew ;

Eder, Joseph Paul ;

Jaeger, Dirk ;

Pietanza, M. Catherine ;

Le, Dung T. ;

de Braud, Filippo ;

Morse, Michael A. ;

Ascierto, Paolo A. ;

Horn, Leora ;

Amin, Asim ;

Pillai, Rathi N. ;

Evans, Jeffry ;

Chau, Ian ;

Bono, Petri ;

Atmaca, Akin ;

Sharma, Padmanee ;

Harbison, Christopher T. ;

Lin, Chen-Sheng ;

Christensen, Olaf ;

Calvo, Emiliano .

LANCET ONCOLOGY, 2016, 17 (07) :883-895

[5] Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer [J].

Antonia, SJ ;

Mirza, N ;

Fricke, I ;

Chiappori, A ;

Thompson, P ;

Williams, N ;

Bepler, G ;

Simon, G ;

Janssen, W ;

Lee, JH ;

Menander, K ;

Chada, S ;

Gabrilovich, DI .

CLINICAL CANCER RESEARCH, 2006, 12 (03) :878-887

[6] A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors [J].

Atrafi, Florence ;

Groen, Harry J. M. ;

Byers, Lauren A. ;

Garralda, Elena ;

Lolkema, Martijn P. ;

Sangha, Randeep S. ;

Viteri, Santiago ;

Chae, Young Kwang ;

Camidge, D. Ross ;

Gabrail, Nashat Y. ;

Hu, Beibei ;

Tian, Tian ;

Nuthalapati, Silpa ;

Hoening, Elizabeth ;

He, Lei ;

Komarnitsky, Philip ;

Calles, Antonio .

CLINICAL CANCER RESEARCH, 2019, 25 (02) :496-505

[7] Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission [J].

Aupérin, A ;

Arriagada, R ;

Pignon, JP ;

Le Péchoux, C ;

Gregor, A ;

Stephens, RJ ;

Kristjansen, PEG ;

Johnson, BE ;

Ueoka, H ;

Wagner, H ;

Aisner, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (07) :476-484

[8] 70 GY thoracic radiotherapy is feasible concurrent with chemotherapy for limited-stage small-cell lung cancer: Analysis of cancer and leukemia group B study 39808 [J].

Bogart, JA ;

Herndon, JE ;

Lyss, AP ;

Watson, D ;

Miller, AA ;

Lee, ME ;

Turrisi, AT ;

Green, MR .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2004, 59 (02) :460-468

[9]

Brueckl M, 2018, ANN ONCOL, V29, P524

[10] Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1 [J].

Byers, Lauren Averett ;

Wang, Jing ;

Nilsson, Monique B. ;

Fujimoto, Junya ;

Saintigny, Pierre ;

Yordy, John ;

Giri, Uma ;

Peyton, Michael ;

Fan, You Hong ;

Diao, Lixia ;

Masrorpour, Fatemeh ;

Shen, Li ;

Liu, Wenbin ;

Duchemann, Boris ;

Tumula, Praveen ;

Bhardwaj, Vikas ;

Welsh, James ;

Weber, Stephanie ;

Glisson, Bonnie S. ;

Kalhor, Neda ;

Wistuba, Ignacio I. ;

Girard, Luc ;

Lippman, Scott M. ;

Mills, Gordon B. ;

Coombes, Kevin R. ;

Weinstein, John N. ;

Minna, John D. ;

Heymach, John V. .

CANCER DISCOVERY, 2012, 2 (09) :798-811

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