Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats

被引：11
作者：
Jiang, Xiao-wen [1 ]
Qiao, Lu [1 ]
Liu, Lin [1 ]
Zhang, Bin-qing [1 ]
Wang, Xue-wei [1 ]
Han, Yu-wen [1 ]
Yu, Wen-hui [1 ]
机构：
[1] Northeast Agr Univ, Dept Vet Med, 59 Mucai St, Harbin 150030, Heilongjiang, Peoples R China
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2017年 / 2017卷
关键词：
DRAGONS BLOOD; TGF-BETA; APOPTOSIS; CROTON; PROLIFERATION; FIBROBLASTS; CYTOKINES; KNOCKOUT;
D O I：
10.1155/2017/8950516
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Dracorhodin perchlorate (DP) is extracted from Dragon's blood, which is widely used in traditional Chinese medicine, especially in wound healing. The aim of this paper is to investigate the influence of DP ointment, which contained DP dissolved in DMSO and mixed with Vaseline, on cutaneous wound healing in Wistar rats. Forty Wistar rats were divided into two groups: control and DP groups. The skin on the back of each rat was punched with two full-thickness wounds and then treated with the corresponding drug. After 3, 7, 10, 14, and 21 days, four rats were sacrificed for immunological, biochemical, and histological analyses. Compared with the control treatment, DP could significantly promote wound closure. Histological and biochemical analyses of the skin biopsies also showed that DP regulated the expression of inflammatory responses by TNF-alpha and IL-beta and by supporting wound tissue growth and collagen deposition. Western blot revealed that DP could also facilitate the expression of EGF and VEGF proteins. In conclusion, DP promotes wound healing.
引用
收藏
页数：9
相关论文
共 50 条
[41]   Thrombin as important factor for cutaneous wound healing: Comparison of fibrin biomatrices in vitro and in a rat excisional wound healing model [J].
Gugerell, Alfred ;
Pasteiner, Waltraud ;
Nuernberger, Sylvia ;
Kober, Johanna ;
Meinl, Alexandra ;
Pfeifer, Sabine ;
Hartinger, Joachim ;
Wolbank, Susanne ;
Goppelt, Andreas ;
Redl, Heinz ;
Mittermayr, Rainer .
WOUND REPAIR AND REGENERATION, 2014, 22 (06) :740-748
[42]   Deferoxamine modulates cytokines and growth factors to accelerate cutaneous wound healing in diabetic rats [J].
Ram, Mahendra ;
Singh, Vishakha ;
Kumawat, Sanjay ;
Kumar, Dhirendra ;
Lingaraju, Madhu C. ;
Singh, Thakur Uttam ;
Rahal, Anti ;
Tandan, Surendra Kumar ;
Kumar, Dinesh .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2015, 764 :9-21
[43]   Paeoniflorin accelerates foot wound healing in diabetic rats though activating the Nrf2 pathway [J].
Sun, Xiaolong ;
Wang, Xu ;
Zhao, Zhenyu ;
Chen, Jing ;
Li, Cheng ;
Zhao, Gang .
ACTA HISTOCHEMICA, 2020, 122 (08)
[44]   Transplantation of photobiomodulation-preconditioned diabetic stem cells accelerates ischemic wound healing in diabetic rats [J].
Ahmadi, Houssein ;
Amini, Abdollah ;
Fathabady, Fatemeh Fadaei ;
Mostafavinia, Atarodsadat ;
Zare, Fatemeh ;
Ebrahimpour-malekshah, Roohollah ;
Ghalibaf, Mustafa Neshat ;
Abrisham, Matin ;
Rezaei, Fatemehalsadat ;
Albright, Richard ;
Ghoreishi, Seyed Kamran ;
Chien, Sufan ;
Bayat, Mohammad .
STEM CELL RESEARCH & THERAPY, 2020, 11 (01)
[45]   Topical Docosahexaenoic Acid (DHA) Accelerates Skin Wound Healing in Rats and Activates GPR120 [J].
Arantes, Eva L. ;
Dragano, Nathalia ;
Ramalho, Albina ;
Vitorino, Daniele ;
de-Souza, Gabriela F. ;
Lima, Maria H. M. ;
Velloso, Licio A. ;
Araujo, Eliana P. .
BIOLOGICAL RESEARCH FOR NURSING, 2016, 18 (04) :411-419
[46]   Effect of topical nitric oxide donor (0.2 % glyceryl trinitrate) on wound healing in diabetic wistar rats [J].
Ghori, V. ;
Mandavia, Divyesh R. ;
Patel, Tejas K. ;
Tripathi, C. B. .
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES, 2014, 34 (01) :45-49
[47]   Phoenix dactylifera L. sap enhances wound healing in Wistar rats: Phytochemical and histological assessment [J].
Abdennabi, Raed ;
Bardaa, Sana ;
Mehdi, Meriem ;
Rateb, Mostafa E. ;
Raab, Andrea ;
Alenezi, Faizah N. ;
Sahnoun, Zouheir ;
Gharsallah, Neji ;
Belbahri, Lassaad .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016, 88 :443-450
[48]   Celecoxib inhibits early cutaneous wound healing [J].
Fairweather, Mark ;
Heit, Yvonne I. ;
Buie, Justin ;
Rosenberg, Laura M. ;
Briggs, Alexandra ;
Orgill, Dennis P. ;
Bertagnolli, Monica M. .
JOURNAL OF SURGICAL RESEARCH, 2015, 194 (02) :717-724
[49]   Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in Murine Model [J].
Luis Santiago, Juan ;
Maria Galan-Moya, Eva ;
Ramon Munoz-Rodriguez, Jose ;
Angel de la Cruz-Morcillo, Miguel ;
Javier Redondo-Calvo, Francisco ;
Gracia-Fernandez, Ignacio ;
Elias, Peter M. ;
Manuel Perez-Ortiz, Jose ;
Man, Mao-Qiang .
CHINESE JOURNAL OF INTEGRATIVE MEDICINE, 2020, 26 (11) :812-818
[50]   CCN1 accelerates re-epithelialization by promoting keratinocyte migration and proliferation during cutaneous wound healing [J].
Du, Hengyu ;
Zhou, Yiwen ;
Suo, Yingjun ;
Liang, Xiao ;
Chai, Bangda ;
Duan, Ran ;
Huang, Xiaolu ;
Li, Qingfeng .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 505 (04) :966-972
12345