Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats

被引:11
作者
Jiang, Xiao-wen [1 ]
Qiao, Lu [1 ]
Liu, Lin [1 ]
Zhang, Bin-qing [1 ]
Wang, Xue-wei [1 ]
Han, Yu-wen [1 ]
Yu, Wen-hui [1 ]
机构
[1] Northeast Agr Univ, Dept Vet Med, 59 Mucai St, Harbin 150030, Heilongjiang, Peoples R China
关键词
DRAGONS BLOOD; TGF-BETA; APOPTOSIS; CROTON; PROLIFERATION; FIBROBLASTS; CYTOKINES; KNOCKOUT;
D O I
10.1155/2017/8950516
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Dracorhodin perchlorate (DP) is extracted from Dragon's blood, which is widely used in traditional Chinese medicine, especially in wound healing. The aim of this paper is to investigate the influence of DP ointment, which contained DP dissolved in DMSO and mixed with Vaseline, on cutaneous wound healing in Wistar rats. Forty Wistar rats were divided into two groups: control and DP groups. The skin on the back of each rat was punched with two full-thickness wounds and then treated with the corresponding drug. After 3, 7, 10, 14, and 21 days, four rats were sacrificed for immunological, biochemical, and histological analyses. Compared with the control treatment, DP could significantly promote wound closure. Histological and biochemical analyses of the skin biopsies also showed that DP regulated the expression of inflammatory responses by TNF-alpha and IL-beta and by supporting wound tissue growth and collagen deposition. Western blot revealed that DP could also facilitate the expression of EGF and VEGF proteins. In conclusion, DP promotes wound healing.
引用
收藏
页数:9
相关论文
共 50 条
[21]   Chitosan-based copper nanocomposite accelerates healing in excision wound model in rats [J].
Gopal, Anu ;
Kant, Vinay ;
Gopalakrishnan, Anu ;
Tandan, Surendra K. ;
Kumar, Dinesh .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 731 :8-19
[22]   Effects of exosomes derived from fibroblast cells on skin wound healing in Wistar rats [J].
Ahmadpour, Fathollah ;
Rasouli, Hamid Reza ;
Talebi, Samira ;
Golchin, Diba ;
Esmailinejad, Mohammad Reza ;
Razie, Ali .
BURNS, 2023, 49 (06) :1372-1381
[23]   KY19382 Accelerates Cutaneous Wound Healing via Activation of the Wnt/β-Catenin Signaling Pathway [J].
Yoon, Minguen ;
Kim, Eunhwan ;
Seo, Seol Hwa ;
Kim, Geon-Uk ;
Choi, Kang-Yell .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (14)
[24]   ANT2 Accelerates Cutaneous Wound Healing in Aged Skin by Regulating Energy Homeostasis and Inflammation [J].
Woo, Seung-Hwa ;
Mo, Yun Jeong ;
Lee, Yun-Il ;
Park, Ji Hwan ;
Hwang, Daehee ;
Park, Tae Jun ;
Kang, Hee Young ;
Park, Sang Chul ;
Lee, Young -Sam .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2023, 143 (11) :2295-+
[25]   Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil [J].
Castellucci, Lea ;
Jamieson, Sarra E. ;
Almeida, Lucas ;
Oliveira, Joyce ;
Guimaraes, Luiz Henrique ;
Lessa, Marcus ;
Fakiola, Michaela ;
de Jesus, Amelia Ribeiro ;
Miller, E. Nancy ;
Carvalho, Edgar M. ;
Blackwell, Jenefer M. .
INFECTION GENETICS AND EVOLUTION, 2012, 12 (05) :1102-1110
[26]   The role of Smad7 in cutaneous wound healing [J].
Wu, Min-Feng ;
Huang, Jian-Hua ;
Zeng, Qing-Yu ;
Wang, Hong-Wei .
ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY, 2021, 156 (01) :13-19
[27]   Organic light emitting diode improves diabetic cutaneous wound healing in rats [J].
Wu, Xingjia ;
Alberico, Stephanie ;
Saidu, Edward ;
Khan, Sazzadur Rahman ;
Zheng, Shijun ;
Romero, Rebecca ;
Chae, Hyun Sik ;
Li, Sheng ;
Mochizuki, Amane ;
Anders, Juanita .
WOUND REPAIR AND REGENERATION, 2015, 23 (01) :104-114
[28]   Angiogenic and MMPs modulatory effects of icariin improved cutaneous wound healing in rats [J].
Singh, Wangkheirakpam Ramdas ;
Devil, Hijam Shila ;
Kumawat, Sanjay ;
Sadam, Abdul ;
Appukuttan, Aneesha, V ;
Patel, Madhuri R. ;
Lingaraju, Madhu C. ;
Singh, Thakur U. ;
Kumar, Dinesh .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2019, 858
[29]   The effect of low-intensity laser therapy (LILT) on cutaneous wound healing and pain relief in rats [J].
Koo, Hyun-Mo ;
Yong, Min-Sik ;
Na, Sang-Su .
JOURNAL OF PHYSICAL THERAPY SCIENCE, 2015, 27 (11) :3421-3423
[30]   Gene therapy in cutaneous wound healing [J].
Hirsch, Tobias ;
Spielmann, Malte ;
Yao, Feng ;
Eriksson, Elof .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2007, 12 :2507-2518