Weak Molecular Interactions in Clathrin-Mediated Endocytosis

被引：37

作者：

Smith, Sarah M. ^{[1
]}

Baker, Michael ^{[1
]}

Halebian, Mary ^{[1
]}

Smith, Corinne J. ^{[1
]}

机构：

[1] Univ Warwick, Sch Life Sci, Coventry, W Midlands, England

来源：

FRONTIERS IN MOLECULAR BIOSCIENCES | 2017年 / 4卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

clathrin; endocytosis; adaptor-protein; structural biology; molecular interactions; N-TERMINAL DOMAIN; TRANS-GOLGI NETWORK; STRUCTURAL EXPLANATION; CRYSTAL-STRUCTURE; ADAPTER COMPLEX; BINDING-SITE; AP-2; ADAPTER; ARRESTIN/CLATHRIN INTERACTION; FUNCTIONAL DISSECTION; SORTING SIGNALS;

D O I：

10.3389/fmolb.2017.00072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Clathrin-mediated endocytosis is a process by which specific molecules are internalized from the cell periphery for delivery to early endosomes. The key stages in this step-wise process, from the starting point of cargo recognition, to the later stage of assembly of the clathrin coat, are dependent on weak interactions between a large network of proteins. This review discusses the structural and functional data that have improved our knowledge and understanding of the main weak molecular interactions implicated in clathrin-mediated endocytosis, with a particular focus on the two key proteins: AP2 and clathrin.

引用

页数：11

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