A novel facile one-pot synthesis of photothermally responsive carbon polymer dots as promising drug nanocarriers

被引：22
作者：
Consoli, Grazia Maria Letizia [1 ]
Giuffrida, Maria Laura [2 ]
Satriano, Cristina [3 ]
Musumeci, Teresa [4 ]
Forte, Giuseppe [4 ]
Petralia, Salvatore [4 ]
机构：
[1] CNR Inst Biomol Chem, I-95126 Catania, Italy
[2] CNR Inst Crystallog, I-95126 Catania, Italy
[3] Univ Catania, Dept Chem Sci, Lab NanoHybrid Biointerfaces NHBIL, I-95125 Catania, Italy
[4] Univ Catania, Dept Drug Sci & Hlth, I-95125 Catania, Italy
来源：
CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 19期
关键词：
PHOTOLUMINESCENCE;
D O I：
10.1039/d1cc06530k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Luminescent and photothermic carbon polymer dots (CPDs-PNM), composed of a carbonized core and cross-linked chains of poly(N-isopropylacrylamide), were synthetized by a novel, simple, solvent- and reagent-free method. The formation of CPDs-PNM was controlled by both temperature and heating time. The CPDs-PNM exhibited LCST behaviour, high photothermal conversion efficiency, curcumin loading capacity and no toxicity to eukaryotic cells. Proof of concept experiments confirmed an excellent thermally induced drug release activity to be used for photothermally controlled drug release.
引用
收藏
页码：3126 / 3129
页数：5
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