COVID-19 and Older Adults: What We Know

被引：649

作者：

Shahid, Zainab ^{[1
,2
]}

Kalayanamitra, Ricci ^{[3
,4
]}

McClafferty, Brendan ^{[1
]}

Kepko, Douglas ^{[1
]}

Ramgobin, Devyani ^{[5
]}

Patel, Ravi ^{[6
]}

Aggarwal, Chander Shekher ^{[7
]}

Vunnam, Ramarao ^{[6
]}

Sahu, Nitasa ^{[6
]}

Bhatt, Dhirisha ^{[6
]}

Jones, Kirk ^{[8
]}

Golamari, Reshma ^{[6
]}

Jain, Rohit ^{[6
]}

机构：

[1] Lake Erie Coll Osteopath Med, 1858 W Grandview Blvd, Erie, PA 16509 USA

[2] Rowan Univ SOM, Internal Med, Stratford, NJ USA

[3] Penn State Coll Med, Hershey, PA USA

[4] Staten Isl Univ Hosp, Zucker Sch Med Hofstra Northwell, Emergency Med, Staten Isl, NY USA

[5] Touro Coll Osteopath Med, Middletown, NY USA

[6] Penn State Hlth Milton S Hershey Med Ctr, Hershey, PA USA

[7] Univ Coll Med Sci Delhi, Delhi, India

[8] Western Maryland Hlth Syst, Dept Pharm, Cumberland, MD USA

来源：

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 2020年 / 68卷 / 05期

关键词：

coronavirus; COVID-19; mortality; older adults; SARS-CoV-2; CORONAVIRUS;

D O I：

10.1111/jgs.16472

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus that causes COVID-19 infection, has recently emerged and caused a deadly pandemic. Studies have shown that this virus causes worse outcomes and a higher mortality rate in older adults and those with comorbidities such as hypertension, cardiovascular disease, diabetes, chronic respiratory disease, and chronic kidney disease (CKD). A significant percentage of older American adults have these diseases, putting them at a higher risk of infection. Additionally, many adults with hypertension, diabetes, and CKD are placed on angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers. Studies have shown that these medications upregulate the ACE-2 receptor, the very receptor that the SARS-CoV-2 virus uses to enter host cells. Although it has been hypothesized that this may cause a further increased risk of infection, more studies on the role of these medications in COVID-19 infections are necessary. In this review, we discuss the transmission, symptomatology, and mortality of COVID-19 as they relate to older adults, and possible treatments that are currently under investigation.

引用

页码：926 / 929

页数：4

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