Click inspired synthesis of antileishmanial triazolyl O-benzylquercetin glycoconjugates

被引：33
|
作者：
Dwivedi, Pratibha [1 ]
Mishra, Kunj B. [1 ]
Mishra, Bhuwan B. [1 ]
Singh, Nisha [2 ]
Singh, Rakesh K. [2 ]
Tiwari, Vinod K. [1 ]
机构：
[1] Banaras Hindu Univ, Fac Sci, Dept Chem, Ctr Adv Study, Varanasi 221005, Uttar Pradesh, India
[2] Banaras Hindu Univ, Fac Sci, Dept Biochem, Varanasi 221005, Uttar Pradesh, India
来源：
GLYCOCONJUGATE JOURNAL | 2015年 / 32卷 / 3-4期
关键词：
Carbohydrates; Antileishmanial Agents; Flavonoids; Quercetin; Click chemistry; Glycoconjugates; FUTURE DRUG DISCOVERY; 1,3-DIPOLAR CYCLOADDITIONS; CARBOHYDRATE MIMICS; IN-VITRO; CHEMISTRY; LEISHMANIASIS; FLAVONOIDS; PERSPECTIVE; QUERCETIN; CLEAVAGE;
D O I：
10.1007/s10719-015-9582-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The 1,3-dipolar cycloaddition of deoxy-azido sugars 1 with O-benzylquercetin alkynes (5-7) to afford regioselective triazole-linked O-benzylquercetin glycoconjugates (8-10) was investigated in the presence of CuI/DIPEA in dichloromethane. All the developed glycoconjugates (8-10) were evaluated for anti-leishmanial activity against the promastigotes and amastigotes of Leishmania donovani.
引用
收藏
页码：127 / 140
页数：14
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