Click inspired synthesis of antileishmanial triazolyl O-benzylquercetin glycoconjugates

被引：33

作者：

Dwivedi, Pratibha ^{[1
]}

Mishra, Kunj B. ^{[1
]}

Mishra, Bhuwan B. ^{[1
]}

Singh, Nisha ^{[2
]}

Singh, Rakesh K. ^{[2
]}

Tiwari, Vinod K. ^{[1
]}

机构：

[1] Banaras Hindu Univ, Fac Sci, Dept Chem, Ctr Adv Study, Varanasi 221005, Uttar Pradesh, India

[2] Banaras Hindu Univ, Fac Sci, Dept Biochem, Varanasi 221005, Uttar Pradesh, India

来源：

GLYCOCONJUGATE JOURNAL | 2015年 / 32卷 / 3-4期

关键词：

Carbohydrates; Antileishmanial Agents; Flavonoids; Quercetin; Click chemistry; Glycoconjugates; FUTURE DRUG DISCOVERY; 1,3-DIPOLAR CYCLOADDITIONS; CARBOHYDRATE MIMICS; IN-VITRO; CHEMISTRY; LEISHMANIASIS; FLAVONOIDS; PERSPECTIVE; QUERCETIN; CLEAVAGE;

D O I：

10.1007/s10719-015-9582-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 1,3-dipolar cycloaddition of deoxy-azido sugars 1 with O-benzylquercetin alkynes (5-7) to afford regioselective triazole-linked O-benzylquercetin glycoconjugates (8-10) was investigated in the presence of CuI/DIPEA in dichloromethane. All the developed glycoconjugates (8-10) were evaluated for anti-leishmanial activity against the promastigotes and amastigotes of Leishmania donovani.

引用

页码：127 / 140

页数：14

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