Mathematical modeling of energy coupling in mitochondria in frames of proton-chemical hypothesis

被引：0

作者：

Lemeshko, VV ^{[1
]}

Anishkin, AG

机构：

[1] Natl Univ, Medellin, Colombia

[2] Kharkov State Univ, Res Inst Biol, UA-310077 Kharkov, Ukraine

来源：

BIOFIZIKA | 1998年 / 43卷 / 02期

关键词：

mitochondria; ATP; membrane potential; energy coupling; model;

D O I：

暂无

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The dependence of ATP-synthesis and mitochondria respiration rates on membrane potential was analyzed in frames of proton-chemical hypothesis of oxidative phosphorylation. The mathematical and electrical models of the unit of energy coupling are proposed. Computer analysis of the mathematical model allowed to obtain the theoretical dependence of the rates of ATP synthesis and of the respiration on the membrane potential. Both of all are in good qualitative agreement with experimental data, contradicting chemiosmotic hypothesis.

引用

页码：308 / 314

页数：7