Catalytic Asymmetric Reactions Involving the Seven-Membered Cyclic Imine Moieties Present in Dibenzo[b,f][1,4]oxazepines

被引：24

作者：

De Munck, Lode ^{[1
]}

Vila, Carlos ^{[1
]}

Pedro, Jose R. ^{[1
]}

机构：

[1] Univ Valencia, Fac Quim, Dept Quim Organ, Dr Moliner 59, E-46100 Valencia, Spain

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 02期

关键词：

Asymmetric catalysis; Asymmetric synthesis; Cyclic imines; Dibenzoxazepines; Nitrogen heterocycles; Chiral amines; HIV-1; REVERSE-TRANSCRIPTASE; DIRECT MANNICH REACTION; ALDEHYDE-ALKYNE-AMINE; ACCESS; HYDROGENATION; DERIVATIVES; PROPARGYLATION; ALKYNYLATION; ACIDS;

D O I：

10.1002/ejoc.201701279

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The dibenzo[b,f][1,4]oxazepine scaffold is a privileged structure in medicinal chemistry that displays a wide variety of biological and pharmacological activities. However, catalytic asymmetric methodologies for the synthesis of chiral dibenzo[b,f][1,4]oxazepine derivatives are scarce in the literature. This microreview presents an overview of enantioselective reactions in which these cyclic seven-membered imines are used as electrophiles, including their substrate scope, limitations and application to the synthesis of related compounds.

引用

页码：140 / 146

页数：7

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