Prevalence of Murine Norovirus Infection in Korean Laboratory Animal Facilities

被引：17

作者：

Kim, Jong Rhan ^{[1
,2
]}

Seok, Seung Hyeok ^{[2
]}

Kim, Dong Jae ^{[2
]}

Baek, Min-Won ^{[2
]}

Na, Yi-Rang ^{[2
]}

Han, Ju-Hee ^{[2
]}

Kim, Tae-Hyun ^{[2
]}

Park, Jae-Hak ^{[2
]}

Turner, Patricia V. ^{[4
]}

Chung, Doo Hyun ^{[1
]}

Kang, Byeong-Cheol ^{[1
,3
]}

机构：

[1] Seoul Natl Univ Hosp, Biomed Res Inst, Seoul 110799, South Korea

[2] Seoul Natl Univ, Coll Vet Med, Dept Lab Anim Med, Seoul 151742, South Korea

[3] Seoul Natl Univ, Coll Med, Grad Sch Immunol, Seoul 110744, South Korea

[4] Univ Guelph, Ontario Vet Coll, Dept Pathol, Guelph, ON N1G 2W1, Canada

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2011年 / 73卷 / 05期

关键词：

genetically modified mouse; Korea; murine norovirus; prevalence; MURINE-NOROVIRUS-1; INFECTION; MICE;

D O I：

10.1292/jvms.10-0226

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Currently, murine noroviruses (MNV) are the most prevalent viral pathogens identified in laboratory animal facilities. While several reports exist concerning the prevalence of MNV in North American research facilities, very few reports are available for other parts of the world, including Korea. This study evaluated the prevalence of MNV infection in 745 murine sera collected from IS animal facilities in Korea by enzyme linked immunosorbent assay (ELISA). Positive cases were subcategorized by murine strain/genetics, housing environments and animal sources. In summary, 6.6% of inbred/outbred mice purchased from commercial vendors were seropositive, 9.6% of in-house colonies were seropositive and 27.0% of genetically modified mice (GMM) were seropositive. Partial gene amplification of fecal isolates from infected animals showed that they were homologous (100%) with MNV-4.

引用

页码：687 / 691

页数：5

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