Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate

Brain and serum lipid peroxidation was studied in rats treated with vincristine sulphate and different doses of nandrolone decanoate. Thirty rats were distributed into six groups (n=5). The treatments were applied once a week for two weeks. Sample collection was performed in the third week. Treatments during the first week were: G1 (control) - physiologic solution, G2- vincristine sulphate (4mg/m(2)), G3-physiologic solution, G4- physiologic solution, G5- vincristine sulphate (4mg/m(2)), and G6- vincristine sulphate (4mg/m(2)). In the second week, they were: G1 (control) - physiologic solution, G2- physiologic solution, G3- nandrolone decanoate (1.8mg/kg(-1)), G4- nandrolone decanoate (10mg/kg(-1)), G5-nandrolone decanoate (1.8mg/kg(-1)), and G6- nandrolone decanoate (10mg/kg(-1)). Lipid peroxidation increased with the isolated use of vincristine and nandrolone decanoate, and with vincristine associated to the highest dose of the ester as well. These results suggest that vincristine sulphate and nandrolone decanoate increase free radical production. Therapeutic dose of nandrolone decanoate when associated with vincristine sulphate proved to be beneficial, as it was able to protect the organism from damaging processes involved in free radical production.