Diphenylprolinol silyl ethers as efficient organocatalysts for the asymmetric Michael reaction of aldehydes and nitroalkenes

被引：1162

作者：

Hayashi, Y ^{[1
]}

Gotoh, H ^{[1
]}

Hayashi, T ^{[1
]}

Shoji, M ^{[1
]}

机构：

[1] Sci Univ Tokyo, Fac Engn, Dept Ind Chem, Shinjuku Ku, Tokyo 1628601, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 27期

关键词：

asymmetric catalysis; diphenylprolinol; Michael addition; nitroalkenes; organocatalysis;

D O I：

10.1002/anie.200500599

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The direct, catalytic, asymmetric Michael addition of aldehydes to nitroolefins in the presence of a chiral diphenylprolinol silyl ether organocatalyst is described (see scheme). The desired 1,4-addition products were obtained in nearly optically pure form in good yield with high syn diastereoselectivity. TMS = trimethylsilyl. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4212 / 4215

页数：4

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