Development and Performance of a Controllable Autoloading Needle-Free Jet Injector

被引：27

作者：

Hemond, Brian D. ^{[1
]}

Taberner, Andrew ^{[1
]}

Hogan, Cathy ^{[1
]}

Crane, Bryan ^{[1
]}

Hunter, Ian W. ^{[1
]}

机构：

[1] MIT, Dept Mech Engn, Cambridge, MA 02139 USA

来源：

JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME | 2011年 / 5卷 / 01期

关键词：

PENETRATION; DELIVERY; SKIN;

D O I：

10.1115/1.4003330

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A jet injector platform technology that provides improved performance over existing jet injectors through the use of a controllable linear Lorentz-force actuator and software-based control system has been developed. Injectors designed on this platform are capable of delivering injections using arbitrary pressure pulse shaping. Pulse shaping has been shown to allow a wide degree of control over the depth to which the injection is delivered. A software-based injector control system improves repeatability and allows for automatic reloading of the injector, a task that would be difficult to implement using existing jet injector platforms. A design for a prototype autoloading controllable jet injector (cJI) based on this platform is detailed. The injection capability of this cJI was evaluated both in-vitro and in-vivo using a tissue analog, excised porcine tissue, and ovine tissue. An analysis of the cJI's performance indicates that this design is capable of delivering a controllable volume of fluid to a controllable depth based entirely on the parameter's input into the control software. [DOI: 10.1115/1.4003330]

引用

页数：7

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