Association Study of Energy Homeostasis Genes and Antipsychotic-Induced Weight Gain in Patients with Schizophrenia

被引：38

作者：

Jassim, G. ^{[1
,2
]}

Ferno, J. ^{[1
,2
]}

Theisen, F. M. ^{[3
]}

Haberhausen, M. ^{[3
]}

Christoforou, A. ^{[1
,2
]}

Havik, B. ^{[1
,2
]}

Gebhardt, S. ^{[4
]}

Remschmidt, H. ^{[3
]}

Mehler-Wex, C. ^{[6
]}

Hebebrand, J. ^{[5
]}

LeHellard, S. ^{[1
,2
]}

Steen, V. M. ^{[1
,2
]}

机构：

[1] Haukeland Hosp, Ctr Med Genet & Mol Med, Dr Einar Martens Res Grp Biol Psychiat, N-5021 Bergen, Norway

[2] Univ Bergen, Dept Clin Med, Bergen, Norway

[3] Univ Marburg, Dept Child & Adolescent Psychiat & Psychotherapy, Marburg, Germany

[4] Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany

[5] Univ Duisburg Essen, Dept Child & Adolescent Psychiat, Essen, Germany

[6] Univ Ulm, Dept Child & Adolescent Psychiat & Psychotherapy, Ulm, Germany

来源：

PHARMACOPSYCHIATRY | 2011年 / 44卷 / 01期

关键词：

ACTIVATED PROTEIN-KINASE; 5-HT2C RECEPTOR GENE; BODY-MASS INDEX; METABOLIC SYNDROME; DRUG-NAIVE; ATYPICAL ANTIPSYCHOTICS; PROMOTER REGION; POLYMORPHISM; CLOZAPINE; ADIPONECTIN;

D O I：

10.1055/s-0030-1263174

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Introduction: Marked inter-individual variation has been observed with respect to the risk of weight gain and related metabolic disturbances during antipsychotic treatment, which in part could be explained by heritability. Such adverse effects have been proposed to occur through drug-induced mechanisms involving both the central nervous system and different peripheral tissues. Methods: We genotyped tagSNPs in several genes (ADIPOQ, PRICAA1, PRICAA2, PRICAB1, PRKAG1, PRKAG2, PRKAG3, FTO and FABP3) that regulate lipid and energy homeostasis for their possible association to antipsychotic-induced weight gain. Results: In a sample of 160 patients of German origin with schizophrenia who had been monitored with respect to body weight, we found marked association between antipsychoticrelated changes in BMI and 6 markers in the adiponectin gene (ADIPOQ). Discussion: These findings support previous observations (in patients' serum) that adiponectin is involved in antipsychotic-mediated metabolic adverse effects.

引用

页码：15 / 20

页数：6

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