Synthesis and Biological Studies of Some New Thiazoles, Hydrazones and Azine Derivatives Based on 3,5-Diphenylcyclohex-2-en-1-one

被引：14
作者：
Abdel-Galil, Ebrahim [1 ]
Girges, Margret M. [1 ]
Said, Gehad E. [1 ]
机构：
[1] Mansoura Univ, Fac Sci, Chem Dept, ET-35516 Mansoura, Egypt
来源：
CHEMISTRYSELECT | 2020年 / 5卷 / 10期
关键词：
Aldehydes; Antibacterial Activity; Azine Derivatives; Hydrazones; Thiazoles; ANTIMICROBIAL ACTIVITY; ALLYLIC OXIDATION; DESIGN;
D O I：
10.1002/slct.201904770
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
3,5-Diphenylcyclohex-2-en-1-one (1) was used as a starting material for the synthesis of new derivatives of hydrazones 3, 4, organic compounds that involves thiazole ring 5-8 and azine moieties 10-17. The biological activity, minimum inhibitory concentration (MIC) and cytotoxicity values of the most active compounds of these derivatives were screened. Compounds 7a, 7b and 8b revealed the best results against all screened biological activity. Derivatives 7a, 7b and 8b revealed moderate to weak cytotoxicity.
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收藏
页码：3075 / 3079
页数：5
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