Graft and crosslinked polymerization of polysaccharide gum to form hydrogel wound dressings for drug delivery applications

被引：43

作者：

Singh, Baljit ^{[1
]}

Kumar, Ajay ^{[1
]}

机构：

[1] Himachal Pradesh Univ, Dept Chem, Shimla 171005, India

来源：

CARBOHYDRATE RESEARCH | 2020年 / 489卷

关键词：

Polysaccharides gum; Grafting; Hydrogels; Levofloxacin; Wound dressings; MORINGA-OLEIFERA GUM; CHITOSAN; RADIATION; RELEASE; FILMS; BIOADHESIVE; BACTERIA; MATRICES; CHITIN;

D O I：

10.1016/j.carres.2020.107949

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present article discusses the exploration of the potential of moringa gum (MOG) polysaccharides for developing a hydrogel dressing as a slow drug carrier to the enhanced wound healing. The polymer films were formed by grafting of carbomer onto MOG by radiation induced crosslinking technique. The polymers were characterized by cryo-SEM, AFM, FTIR, C-13 NMR spectroscopy, and swelling studies. Drug delivery and biomedical properties of the dressings were also determined. Polymer dressing absorbed 4.20 +/- 0.09 g/g simulated wound fluid. The release of levofloxacin was observed without burst effect and followed non-Fickian diffusion mechanism and best fitted in Higuchi kinetic model. The hydrogel films were permeable to O-2 and H2O vapour and impermeable to microbes and showed antioxidant activity.

引用

页数：9

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