Synthesis and application of a novel solid-phase microextraction adsorbent: Hollow fiber supported carbon nanotube reinforced sol-gel for determination of phenobarbital

被引:84
作者
Es'haghi, Zarrin [1 ,2 ]
Rezaeifar, Zohreh [1 ]
Rounaghi, Gholam-Hossein [3 ]
Nezhadi, Zahra Alian [1 ]
Golsefidi, Mazyar Ahmadi [1 ]
机构
[1] Payame Noor Univ, Fac Sci, Dept Chem, Mashhad, Iran
[2] Ferdowsi Univ Mashhad, Fac Sci, Res & Technol Ctr Bio Mol, Mashhad, Iran
[3] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Mashhad, Iran
关键词
Phenobarbital; Solid-phase microextraction; Sol-gel; Carbon nanotube; Hollow fiber; PERFORMANCE LIQUID-CHROMATOGRAPHY; PHARMACEUTICAL RESIDUES; EXTRACTION; SILICA; ANTICONVULSANT; CALIBRATION; ENRICHMENT; EFFLUENTS; SPME; PORK;
D O I
10.1016/j.aca.2011.01.019
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A novel solid-phase microextraction technique using a hollow fiber-supported sol-gel combined with multi-walled carbon nanotubes was employed in the determination of phenobarbital in wastewater. In this new technique, a silica-based, organic-inorganic polymer containing functionalized multi-walled carbon nanotubes (MWCNTs) was prepared with sol-gel technology via the reaction of tetraethylorthosilicate (TEOS) with an acidic catalyst (HCl). This sol was injected into a polypropylene hollow fiber segment for in situ gelation. This device operated in direct immersion sampling mode. The experimental setup is simple and affordable, and the device is disposable, so there is no risk of cross-contamination or carry-over. Parameters affecting extraction such as pH of the aqueous solution, ageing and extraction times, aqueous sample volume, agitation speed and carbon nanotube amount were optimized. Linearity was observed over a range of 0.50-5000 ng mL(-1), with an estimation coefficient (r(2)) higher than 0.982. The limit of detection (LOD) was 0.32 ng mL(-1) (n = 5), and repeatability (RSD% = 2.9) was from the average of three levels of analyte concentrations (1, 1000 and 4500 ng mL(-1)) with three replicates for each within a single day. Finally, a pre-concentration factor of 2100 was obtained for phenobarbital. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:122 / 128
页数:7
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