Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent

被引：29

作者：

Frescas, David ^{[1
]}

Hall, Brandon M. ^{[1
]}

Strom, Evguenia ^{[1
]}

Virtuoso, Lauren P. ^{[1
]}

Gupta, Mahima ^{[1
]}

Gleiberman, Anatoli S. ^{[1
]}

Rydkina, Elena ^{[1
]}

Balan, Vitaly ^{[1
]}

Vujcic, Slavoljub ^{[1
]}

Chernova, Olga B. ^{[1
]}

Gudkov, Andrei V. ^{[1
,2
]}

机构：

[1] Everon Biosci Inc, Buffalo, NY USA

[2] Roswell Pk Canc Inst, Dept Cell Stress Biol, Buffalo, NY 14203 USA

来源：

CELL CYCLE | 2017年 / 16卷 / 16期

关键词：

p16(Ink4a); senescence; biomarkers; senescence-associated -galactosidase (SA-Gal); healthspan; MICE; PROLIFERATION; CLEARANCE; MARKERS;

D O I：

10.1080/15384101.2017.1339850

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Age-related health decline has been attributed to the accumulation of senescent cells recognized in vivo by p16(Ink4a) expression. The pharmacological elimination of p16(Ink4a)-positive cells from the tissues of mice was shown to extend a healthy lifespan. Here, we describe a population of mesenchymal cells isolated from mice that are highly p16(INK4a)-positive are proficient in proliferation but lack other properties of cellular senescence. These data, along with earlier reports on p16(Ink4a)-positive macrophages, indicate that p16(Ink4a)-positive and senescent cell populations only partially intersect, therefore, extending the list of potential cellular targets for anti- aging therapies.

引用

页码：1526 / 1533

页数：8

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