Microbiota-Gut-Brain Communication in the SARS-CoV-2 Infection

被引：20

作者：

Manosso, Luana M. ^{[1
]}

Arent, Camila O. ^{[1
]}

Borba, Laura A. ^{[1
]}

Ceretta, Luciane B. ^{[2
]}

Quevedo, Joao ^{[1
,3
,4
,5
]}

Reus, Gislaine Z. ^{[1
]}

机构：

[1] Univ Southern Santa Catarina UNESC, Translat Psychiat Lab, Grad Program Hlth Sci, BR-77054000 Criciuma, SC, Brazil

[2] Univ Extremo Sul Catarinense, Programa Posgrad Saude Colet, BR-88806000 Criciuma, SC, Brazil

[3] Univ Texas Hlth Sci Ctr Houston UTHlth, Translat Psychiat Program, Dept Psychiat & Behav Sci, McGovern Med Sch, Houston, TX 77030 USA

[4] Univ Texas Hlth Sci Ctr Houston UTHlth, Ctr Excellence Mood Disorders, Dept Psychiat & Behav Sci, McGovern Med Sch, Houston, TX 77030 USA

[5] Univ Texas Grad Sch Biomed Sci Houston, Neurosci Grad Program, Houston, TX 77030 USA

来源：

CELLS | 2021年 / 10卷 / 08期

基金：

美国国家卫生研究院;

关键词：

microbiota-gut-brain axis; neuroinflammation; SARS-CoV-2; mood disorders; neurological diseases; COVID-19; C-REACTIVE PROTEIN; IMMUNE-SYSTEM; NEURODEGENERATIVE DISEASES; PARKINSONS-DISEASE; ALZHEIMER-DISEASE; FECAL MICROBIOTA; DEPRESSION; INFLAMMATION; COVID-19; PATHOPHYSIOLOGY;

D O I：

10.3390/cells10081993

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The coronavirus disease of 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome 2 (SARS-CoV-2). In addition to pneumonia, individuals affected by the disease have neurological symptoms. Indeed, SARS-CoV-2 has a neuroinvasive capacity. It is known that the infection caused by SARS-CoV-2 leads to a cytokine storm. An exacerbated inflammatory state can lead to the blood-brain barrier (BBB) damage as well as to intestinal dysbiosis. These changes, in turn, are associated with microglial activation and reactivity of astrocytes that can promote the degeneration of neurons and be associated with the development of psychiatric disorders and neurodegenerative diseases. Studies also have been shown that SARS-CoV-2 alters the composition and functional activity of the gut microbiota. The microbiota-gut-brain axis provides a bidirectional homeostatic communication pathway. Thus, this review focuses on studies that show the relationship between inflammation and the gut microbiota-brain axis in SARS-CoV-2 infection.

引用

页数：17

共 182 条

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