Biochemistry of oxidative stress

被引:1061
作者
Halliwell, B. [1 ]
机构
[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117597, Singapore
关键词
antioxidant; cancer; cell culture; oxidative damage; oxidative stress; senescence;
D O I
10.1042/BST0351147
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The terms 'antioxidant', 'oxidative stress' and 'oxidative damage' are widely used but rarely defined. This brief review attempts to define them and to examine the ways in which oxidative stress and oxidative damage can affect cell behaviour both in vivo and in cell culture, using cancer as an example.
引用
收藏
页码:1147 / 1150
页数:4
相关论文
共 49 条
[31]   Artifacts in cell culture: Rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media [J].
Long, LH ;
Clement, MV ;
Halliwell, B .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 273 (01) :50-53
[32]   Gene regulation and DNA damage in the ageing human brain [J].
Lu, T ;
Pan, Y ;
Kao, SY ;
Li, C ;
Kohane, I ;
Chan, J ;
Yankner, BA .
NATURE, 2004, 429 (6994) :883-891
[33]   Irreversible thiol oxidation in carbonic anhydrase III: Protection by S-glutathiolation and detection in aging rats [J].
Mallis, RJ ;
Hamann, MJ ;
Zhao, W ;
Zhang, TQ ;
Hendrich, S ;
Thornas, JA .
BIOLOGICAL CHEMISTRY, 2002, 383 (3-4) :649-662
[34]   Regulation of ion channel structure and function by reactive oxygen-nitrogen species [J].
Matalon, S ;
Hardiman, KM ;
Jain, L ;
Eaton, DC ;
Kotlikoff, M ;
Eu, JP ;
Sun, JH ;
Meissner, G ;
Stamler, JS .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2003, 285 (06) :L1184-L1189
[35]   The role of calcium in the regulation of apoptosis [J].
McConkey, DJ ;
Orrenius, S .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 239 (02) :357-366
[36]   Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans [J].
Murphy, CT ;
McCarroll, SA ;
Bargmann, CI ;
Fraser, A ;
Kamath, RS ;
Ahringer, J ;
Li, H ;
Kenyon, C .
NATURE, 2003, 424 (6946) :277-284
[37]   Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling [J].
Nathan, C .
JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (06) :769-778
[38]   Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels [J].
Perraud, AL ;
Takanishi, CL ;
Shen, B ;
Kang, S ;
Smith, MK ;
Schmitz, C ;
Knowles, HM ;
Ferraris, D ;
Li, WX ;
Zhang, J ;
Stoddard, BL ;
Scharenberg, AM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (07) :6138-6148
[39]   Global adjustment of microbial physiology during free radical stress [J].
Pomposiello, PJ ;
Demple, B .
ADVANCES IN MICROBIAL PHYSIOLOGY, VOL 46, 2002, 46 :319-341
[40]   Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins [J].
Rhee, SG ;
Kang, SW ;
Jeong, W ;
Chang, TS ;
Yang, KS ;
Woo, HA .
CURRENT OPINION IN CELL BIOLOGY, 2005, 17 (02) :183-189