Biochemistry of oxidative stress

被引:1060
作者
Halliwell, B. [1 ]
机构
[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117597, Singapore
关键词
antioxidant; cancer; cell culture; oxidative damage; oxidative stress; senescence;
D O I
10.1042/BST0351147
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The terms 'antioxidant', 'oxidative stress' and 'oxidative damage' are widely used but rarely defined. This brief review attempts to define them and to examine the ways in which oxidative stress and oxidative damage can affect cell behaviour both in vivo and in cell culture, using cancer as an example.
引用
收藏
页码:1147 / 1150
页数:4
相关论文
共 49 条
[21]   Free radicals, proteins and DNA: Oxidative damage versus redox regulation [J].
Halliwell, B .
BIOCHEMICAL SOCIETY TRANSACTIONS, 1996, 24 (04) :1023-1027
[22]   THE DEFINITION AND MEASUREMENT OF ANTIOXIDANTS IN BIOLOGICAL-SYSTEMS [J].
HALLIWELL, B ;
GUTTERIDGE, JMC .
FREE RADICAL BIOLOGY AND MEDICINE, 1995, 18 (01) :125-126
[23]  
Halliwell B., 2000, FREE RADICAL BIO MED, V3rd
[24]   Oxidative stress and cancer: have we moved forward? [J].
Halliwell, Barry .
BIOCHEMICAL JOURNAL, 2007, 401 (1-11) :1-11
[25]   Dietary polyphenols: Good, bad, or indifferent for your health? [J].
Halliwell, Barry .
CARDIOVASCULAR RESEARCH, 2007, 73 (02) :341-347
[26]   Phagocyte-derived reactive species: salvation or suicide? [J].
Halliwell, Barry .
TRENDS IN BIOCHEMICAL SCIENCES, 2006, 31 (09) :509-515
[27]   Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life [J].
Halliwell, Barry .
PLANT PHYSIOLOGY, 2006, 141 (02) :312-322
[28]   Stochastic and genetic factors influence tissue-specific decline in ageing C-elegans [J].
Herndon, LA ;
Schmeissner, PJ ;
Dudaronek, JM ;
Brown, PA ;
Listner, KM ;
Sakano, Y ;
Paupard, MC ;
Hall, DH ;
Driscoll, M .
NATURE, 2002, 419 (6909) :808-814
[29]   Mechanisms of cellular senescence in human and mouse cells [J].
Itahana, K ;
Campisi, J ;
Dimri, GP .
BIOGERONTOLOGY, 2004, 5 (01) :1-10
[30]   Can apple antioxidants inhibit tumor cell proliferation?: Generation of H2O2 during interaction of phenolic compounds with cell culture media [J].
Lapidot, T ;
Walker, MD ;
Kanner, J .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2002, 50 (11) :3156-3160