Kainate receptors and synaptic plasticity

被引：27

作者：

Nair, Jithin D. ^{[1
]}

Wilkinson, Kevin A. ^{[1
]}

Henley, Jeremy M. ^{[1
,3
]}

Mellor, Jack R. ^{[2
]}

机构：

[1] Univ Bristol, Sch Biochem, Ctr Synapt Plast, Univ Walk, Bristol BS8 1TD, Avon, England

[2] Univ Bristol, Sch Physiol Pharmacol & Neurosci, Ctr Synapt Plast, Univ Walk, Bristol BS8 1TD, Avon, England

[3] Univ Technol Sydney, Fac Sci, Ctr Neurosci & Regenerat Med, Ultimo, NSW, Australia

来源：

NEUROPHARMACOLOGY | 2021年 / 196卷

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

Kainate receptors; Synaptic plasticity; Hippocampus; CA3; Mossy fiber; MOSSY-FIBER SYNAPSES; AUTISM SPECTRUM DISORDERS; LONG-TERM POTENTIATION; GLUTAMATE RECEPTORS; SURFACE EXPRESSION; SUBUNIT; TRANSMISSION; FACILITATION; TRAFFICKING; RELEASE;

D O I：

10.1016/j.neuropharm.2021.108540

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Synaptic plasticity has classically been characterized to involve the NMDA and AMPA subtypes of glutamate receptors, with NMDA receptors providing the key trigger for the induction of long-term plasticity leading to changes in AMPA receptor expression. Here we review the more subtle roles played by kainate receptors, which contribute critical postsynaptic signalling as well as playing major presynaptic auto-receptor roles. We focus on two research areas: plasticity of kainate receptors themselves and the contribution they make to the plasticity of synaptic transmission. This article is part of the special issue on Glutamate Receptors - Kainate receptors.

引用

页数：7

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