Evidence of a direct action of taurine and calcium on biological membranes - A combined study of P-11-nuclear magnetic resonance and electron spin resonance

被引：14

作者：

Nakashima, T ^{[1
]}

Shima, T ^{[1
]}

Sakai, M ^{[1
]}

Yama, H ^{[1
]}

Mitsuyoshi, H ^{[1
]}

Inaba, K ^{[1
]}

Matsumoto, N ^{[1
]}

Sakamoto, Y ^{[1
]}

Kashima, K ^{[1
]}

Nishikawa, H ^{[1
]}

机构：

[1] MEIJI COLL ORIENTAL MED,DEPT PHYSIOL,KYOTO,JAPAN

来源：

BIOCHEMICAL PHARMACOLOGY | 1996年 / 52卷 / 01期

关键词：

taurine; calcium; fluidity; erythrocyte ghost; P-31-NMR; ESR;

D O I：

10.1016/0006-2952(96)00166-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To determine the actions of taurine and calcium on biological membranes, the effects of these compounds on the mobility of phospholipids of resealed and sonicated ghosts of human erythrocytes were investigated, using P-31-NMR spectroscopy. In addition, the effects of taurine and calcium on lipid fluidity were investigated by ESR spectroscopy, using a spin-labeling method with 5-doxyl stearic acid. The mobility of the membranes decreased following treatment with 10 mM taurine, but coadministration of 2.5 mM calcium blocked this effect. The fluidity of the membranes was not changed following treatment with 10 mM taurine, but decreased following coadministration of 2.5 mM calcium. These actions of taurine and calcium on the dynamics of biological membranes might explain, in part, the observation that most of the pharmacological effects of taurine on mammalian organs occur in the presence of calcium ions.

引用

页码：173 / 176

页数：4

共 21 条

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