Pathophysiology of vascular calcification Pivotal role of cellular senescence in vascular smooth muscle cells

被引：92

作者：

Burton, D. G. A. ^{[1
]}

Matsubara, H. ^{[2
]}

Ikeda, K. ^{[2
]}

机构：

[1] Univ Miami, Dept Med, Div Gerontol & Geriatr Med, Miami, FL 33125 USA

[2] Kyoto Prefectural Univ, Sch Med, Dept Cardiovasc Med, Kyoto 606, Japan

来源：

EXPERIMENTAL GERONTOLOGY | 2010年 / 45卷 / 11期

关键词：

Cellular senescence; Vascular calcification; Vascular smooth muscle; Ageing; RUNX; 2; SASP; CESP; BONE MORPHOGENETIC PROTEIN-2; OSTEOBLAST DIFFERENTIATION; CORONARY CALCIFICATION; MOLECULAR-MECHANISMS; GENE-EXPRESSION; CLINICAL-SIGNIFICANCE; PREMATURE SENESCENCE; ARTERY CALCIFICATION; TARGET GENES; IN-VITRO;

D O I：

10.1016/j.exger.2010.07.005

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The accumulation of senescent cells within tissues can potentially lead to biological dysfunction and manifestation of disease associated with ageing The majority of senescent cells display a commonly altered secretome similar to a wound healing response (termed the senescence-associated secretory phenotype or SASP) which could have deleterious implications on the tissue microenvironment However senescent cells also appear to have a cell-type (or even cell strain) exclusive senescent phenotype (CESP) an area of research that is underexplored One such CESP is the pro-calcificatory phenotype recently reported in senescent vascular smooth muscle cells (VSMCs) Senescent VSMCs have been shown to overexpress genes and proteins (Including RUNX-2 alkaline phosphatase (ALP) type I collagen and BMP-2) associated with osteoblasts leading to partial osteoblastic transdifferentiation As such It has been suggested that senescent VSMCs contribute to cardiovascular dysfunction through induction of vascular calcification This review discusses recent findings on VSMC senescence and their potential role in the pathophysiology of vascular calcification (C) 2010 Elsevier Inc All rights reserved

引用

页码：819 / 824

页数：6

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