Bcl-2 mediates induction of neural differentiation

被引：25
作者：
Liang, Y
Mirnics, ZK
Yan, CH
Nylander, KD
Schor, NF
机构：
[1] Univ Pittsburgh, Div Child Neurol, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Pediat Ctr Neurosci, Pittsburgh, PA 15213 USA
[3] Childrens Hosp Pittsburgh, Pittsburgh, PA 15213 USA
来源：
ONCOGENE | 2003年 / 22卷 / 35期
关键词：
neural differentiation; TrkA; nerve growth factor; Bcl-2; DNA microarray;
D O I：
10.1038/sj.onc.1206844
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bcl-2 is an antiapoptotic protein expressed in a wide variety of cell types. We have found that overexpression of bcl-2 in PC12 neural crest tumor cells leads to increased expression of neural differentiation-associated genes and decreased expression of proliferation-related genes. Culture growth rate decreases as well. Overexpression of bcl-2 also leads to increased expression of TrkA and increased phosphorylation of signal transductants in, albeit not specific for, the TrkA-MEK-ERK pathway. Blocking of NGF-mediated signaling through TrkA prevents Bcl-2-associated expression changes in differentiation-associated genes, raising the possibility that Bcl-2 mediates induction of neural differentiation through TrkA/NGF signaling.
引用
收藏
页码：5515 / 5518
页数：4
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