Development of computational models for enzymes, transporters, channels, and receptors relevant to ADME/Tox

被引：39
作者：
Ekins, S
Swaan, PW
机构：
[1] GeneCo, St Joseph, MI 49085 USA
[2] Univ Maryland, Dept Pharmaceut Sci, Baltimore, MD 21201 USA
来源：
REVIEWS IN COMPUTATIONAL CHEMISTRY, VOL 20 | 2004年 / 20卷
关键词：
D O I：
10.1002/0471678856.ch6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[No abstract available]
引用
收藏
页码：333 / 415
页数：83
相关论文
共 429 条
[71]   A PREDICTIVE SUBSTRATE MODEL FOR RAT GLUTATHIONE-S-TRANSFERASE-4-4 [J].
DEGROOT, MJ ;
VANDERAAR, EM ;
NIEUWENHUIZEN, PJ ;
VANDERPLAS, RM ;
DENKELDER, GMDO ;
COMMANDEUR, JNM ;
VERMEULEN, NPE .
CHEMICAL RESEARCH IN TOXICOLOGY, 1995, 8 (05) :649-658
[72]   Identification of the cyclosporin-binding site in P-glycoprotein [J].
Demeule, M ;
Laplante, A ;
Murphy, GF ;
Wenger, RM ;
Béliveau, R .
BIOCHEMISTRY, 1998, 37 (51) :18110-18118
[73]   Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein [J].
Dey, S ;
Ramachandra, M ;
Pastan, I ;
Gottesman, MM ;
Ambudkar, SV .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (20) :10594-10599
[74]   Bioactive diversity and screening library selection via affinity fingerprinting [J].
Dixon, SL ;
Villar, HO .
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 1998, 38 (06) :1192-1203
[75]   cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome p450 [J].
Domanski, TL ;
Finta, C ;
Halpert, JR ;
Zaphiropoulos, PG .
MOLECULAR PHARMACOLOGY, 2001, 59 (02) :386-392
[76]   Analysis of four residues within substrate recognition site 4 of human cytochrome p450 3A4:: Role in steroid hydroxylase activity and α-naphthoflavone stimulation [J].
Domanski, TL ;
Liu, JP ;
Harlow, GR ;
Halpert, JR .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1998, 350 (02) :223-232
[77]   Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity [J].
Domanski, TL ;
He, YA ;
Khan, KK ;
Roussel, F ;
Wang, QM ;
Halpert, JR .
BIOCHEMISTRY, 2001, 40 (34) :10150-10160
[78]   Minimal molecular determinants of substrates for recognition by the intestinal peptide transporter [J].
Döring, F ;
Will, J ;
Amasheh, S ;
Clauss, W ;
Ahlbrecht, H ;
Daniel, H .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (36) :23211-23218
[79]  
Dresser MJ, 2001, J PHARM SCI, V90, P397, DOI 10.1002/1520-6017(200104)90:4<397::AID-JPS1000>3.0.CO
[80]  
2-D
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