Association between abdominal fat distribution, adipocytokines and metabolic alterations in obese low-birth-weight children

BackgroundIn addition to obesity, low birth weight (LBW) has been proposed as another independent risk factor associated with cardiovascular disease and type 2 diabetes mellitus. ObjectiveThis study aimed to evaluate the influence of birth weight on abdominal fat distribution, adipocytokine levels and associated metabolic alterations in obese children. MethodsA cross-sectional study was conducted in 92 children. Children were divided into three groups according to their body mass index and birth weight. Glucose and insulin (0 and 120min), lipid profile and adipocytokines were measured. Abdominal fat distribution was assessed by magnetic resonance imaging. ResultsObese LBW children had higher fasting glucose (P=0.054) and insulin (P<0.001), and 120min glucose (P<0.001) and insulin levels (P<0.001), such as increased HOMA-IR (homeostasis model assessment of insulin resistance index) (P<0.001). Obesity and LBW were associated with lower concentrations of high molecular weight (HMW) adiponectin (-2.38 [IC 95% -4.27; -0.42, P=0.018]) and higher subcutaneous adipose tissue (SAT) (28.05 [IC 95% 0.40; 55.7, P=0.047]) compared with NBW obese children, independent of age or sex. ConclusionsLBW in obese children is associated with lower HMW adiponectin, increased insulin resistance and greater SAT.