Metabolic Syndrome and Endothelial Dysfunction in a Population Born Small for Gestational Age Relationship to Growth and Gh Therapy

被引：0

作者：

de Arriba, Antonio ^{[1
,2
]}

Dominguez, Mercedes ^{[3
]}

Labarta, Jose I. ^{[4
]}

Dominguez, Manuel ^{[4
]}

Puga, Beatriz ^{[1
]}

Mayayo, Esteban ^{[4
]}

Ferrandez Longas, Angel ^{[1
]}

机构：

[1] Govt Aragon, Inst Hlth Sci, IACS, Andrea Prader Fdn, Zaragoza, Spain

[2] Obispo Polanco Hosp, Teruel, Spain

[3] Barbastro Hosp, Barbastro, Spain

[4] Miguel Servet Univ, Childrens Hosp, Zaragoza, Spain

来源：

PEDIATRIC ENDOCRINOLOGY REVIEWS PER | 2013年 / 10卷 / 03期

关键词：

small for gestational age; metabolic syndrome; carotid intima-media thickness; GH treatment;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Being born small for gestational age (SGA) and a rapid increase in weight during early childhood and infancy have been strongly linked to metabolic syndrome. A transversal study was conducted on 167 pre- pubertal and 102 pubertal subjects; auxological parameters, systolic and diastolic blood pressure, laboratory data, and carotid-wall thickness (CA-IMT) were measured. Results: Patients born SGA with spontaneous catch-up growth have higher values of BMI, blood pressure, HOMA index, and CA-IMT than those treated with GH and the appropriate-forgestational age (AGA) group. In conclusion, subjects born SGA are at high risk of developing chronic diseases, including obesity, hypertension, insulin resistance, and endothelial dysfunction, at an early age, mainly those with good catch-up growth compared with those receiving GH because of negative catch-up growth. Our data is compared with published results.

引用

页码：297 / 307

页数：11

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