The effect of l-arginine supplementation on lipid profile: a systematic review and meta-analysis of randomised controlled trials

被引:16
作者
Hadi, Amir [1 ]
Arab, Arman [2 ]
Moradi, Sajjad [3 ]
Pantovic, Ana [4 ]
Clark, Cain C. T. [5 ]
Ghaedi, Ehsan [6 ,7 ]
机构
[1] FDA, Halal Res Ctr IRI, Tehran, Iran
[2] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Food Secur Res Ctr, Esfahan 81745, Iran
[3] Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Nutr Sci Dept, Kermanshah 6719851552, Iran
[4] Univ Belgrade, Inst Med Res, Ctr Res Excellence Nutr & Metab, Belgrade 11000, Serbia
[5] Coventry Univ, Fac Res Ctr Sport Exercise & Life Sci, Coventry CV1 5FB, W Midlands, England
[6] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran 141556446, Iran
[7] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran 141556446, Iran
关键词
l-Arginine; Supplementation; Lipid profile; Systematic reviews; Meta-analyses; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASES; METABOLIC SYNDROME; ADIPOSE-TISSUE; HEART-DISEASE; NITRIC-OXIDE; DYSLIPIDEMIA; PREVENTION; STATINS; GLUCOSE;
D O I
10.1017/S0007114519001855
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
A number of clinical trials have examined the effect of l-arginine on lipid profile in recent years; however, the results remain equivocal. Therefore, the present study aims to summarise and quantitatively examine the available evidence on the effectiveness l-arginine supplementation on lipid parameters using a systematic review and meta-analytic approach. Online databases including PubMed, Scopus, ISI Web of Science, Cochrane Library and Google Scholar were searched up to April 2019 for randomised controlled trials that examined the effect of l-arginine supplementation on lipid profile in adults. Treatment effects were expressed as weighted mean difference (WMD) and the corresponding standard error in concentrations of serum lipids. To estimate the overall effect of l-arginine supplementation, we used the random-effects model. In total, twelve studies were included in the systematic review. The meta-analysis revealed that l-arginine supplementation did not significantly change the concentrations of total cholesterol (WMD: -5 center dot 03 mg/dl; 95 % CI -10 center dot 78, 0 center dot 73; P = 0 center dot 08; inconsistency index (I-2) = 39 center dot 0 %), LDL (WMD: -0 center dot 47 mg/dl; 95 % CI -3 center dot 61, 2 center dot 66; P = 0 center dot 76; I-2 = 0 center dot 0 %), or HDL (WMD: 0 center dot 57 mg/dl; 95 % CI -1 center dot 28, 2 center dot 43; P = 0 center dot 54; I-2 = 68 center dot 4 %). A significant reduction was observed only in serum TAG levels (WMD: -7 center dot 04 mg/dl; 95 % CI -11 center dot 42, -2 center dot 67; P < 0 center dot 001; I-2 = 0 center dot 0 %). This meta-analysis concludes that l-arginine supplementation can significantly reduce blood TAG levels; however, there is insufficient evidence to support its hypocholesterolaemic effects. To draw straightforward conclusions regarding generalised recommendations for l-arginine supplementation for improving lipid profile, there is a need for more well-controlled trials targeting exclusively patients with dyslipidaemia.
引用
收藏
页码:1021 / 1032
页数:12
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