Diagnosis and Management of Autoimmune Myasthenia Gravis

被引:18
作者
Angelini, Corrado [1 ,2 ]
机构
[1] Univ Padua, Dept Neurosci, I-35128 Padua, Italy
[2] IRCSS S Camillo, Venice, Italy
关键词
QUALITY-OF-LIFE; ACETYLCHOLINE-RECEPTOR; MYCOPHENOLATE-MOFETIL; NEUROMUSCULAR-TRANSMISSION; MUSK ANTIBODIES; DOUBLE-BLIND; PYRIDOSTIGMINE; PATIENT; TRIAL; MG;
D O I
10.2165/11584740-000000000-00000
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Earlier diagnosis and the availability of effective treatments have reduced the burden of high mortality and severe disability previously associated with myasthenia gravis (MG). Consequently, the prognosis of MG is now much improved. However, despite extensive knowledge of MG and its aetiology, diagnosing the disease remains problematic and can be delayed because of its nonspecific and fluctuating symptoms, and the management of MG is associated with considerable limitations. Current treatments based on immunomodulation are associated with adverse effects arising from prolonged immune suppression. There is a need for improved awareness among primary caregivers about this relatively rare, but treatable, disease.
引用
收藏
页码:1 / 14
页数:14
相关论文
共 102 条
[51]   Ocular myasthenia: diagnostic and treatment recommendations and the evidence base [J].
Luchanok, Uladzimir ;
Kaminski, Henry J. .
CURRENT OPINION IN NEUROLOGY, 2008, 21 (01) :8-15
[52]  
Magee Mitchell J, 2009, Thorac Surg Clin, V19, P83, DOI 10.1016/j.thorsurg.2008.09.013
[53]  
MAGEE MJ, 2009, THORAC SURG CLIN, V19, pR7
[54]   PSYCHIATRIC DISTURBANCES ASSOCIATED WITH MYASTHENIA-GRAVIS [J].
MAGNI, G ;
MICAGLIO, GF ;
LALLI, R ;
BEJATO, L ;
CANDEAGO, MR ;
MERSKEY, H ;
ANGELINI, C .
ACTA PSYCHIATRICA SCANDINAVICA, 1988, 77 (04) :443-445
[55]   Muscle histopathology in myasthenia gravis with antibodies against MuSK and AChR [J].
Martignago, S. ;
Fanin, M. ;
Albertini, E. ;
Pegoraro, E. ;
Angelini, C. .
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2009, 35 (01) :103-110
[56]  
MCEACHERN D, 1935, CAN MED ASSOC J, P310
[57]  
*MED GROUP, 2010, DAT FIL
[58]   Mycophenolate mofetil for myasthenia gravis - An analysis of efficacy, safety, and tolerability [J].
Meriggioli, MN ;
Ciafaloni, E ;
Al-Hayk, KA ;
Rowin, J ;
Tucker-Lipscomb, B ;
Massey, JM ;
Sanders, DB .
NEUROLOGY, 2003, 61 (10) :1438-1440
[59]   QUANTITATIVE CORRELATION BETWEEN PLASMA PYRIDOSTIGMINE LEVELS AND NEUROMUSCULAR FUNCTION IN MYASTHENIA-GRAVIS [J].
MILNERBROWN, HS ;
MELLENTHIN, M ;
SHARMA, ML ;
MILLER, RG .
NEUROLOGY, 1987, 37 (05) :800-803
[60]   Disease-specific measure of quality of life for myasthenia gravis [J].
Mullins, Larry L. ;
Carpentier, Melissa Y. ;
Paul, Robert H. ;
Sanders, Donald B. .
MUSCLE & NERVE, 2008, 38 (02) :947-956