Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture

被引：66

作者：

Burton, G

Ku, TW

Carr, TJ

Kiesow, T

Sarisky, RT

Lin-Goerke, J

Baker, A

Earnshaw, DL

Hofmann, GA

Keenan, RM

Dhanak, D

机构：

[1] GlaxoSmithKline, Collegeville, PA 19426 USA

[2] GlaxoSmithKline, King Of Prussia, PA 19406 USA

[3] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 06期

关键词：

hepatitis C virus; RNA polymerase; pyrrolidine; combinatorial mixture;

D O I：

10.1016/j.bmcl.2005.01.076

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

HTS of the compound collection for inhibition of the HCV RNA dependent RNA polymerase identified two 168 member N-acyl pyrrolidine combinatorial mixture hits. Deconvolution and expansion of these mixtures by solid phase synthesis to establish initial SAR and identify a potent inhibitor is reported. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1553 / 1556

页数：4

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