Nail Psoriasis: Diagnosis, Assessment, Treatment Options, and Unmet Clinical Needs

被引:31
作者
Kaeley, Gurjit S. [1 ]
Eder, Lihi [2 ]
Aydin, Sibel Zehra [3 ]
Rich, Phoebe [4 ]
Bakewell, Catherine J. [5 ]
机构
[1] Univ Florida, Dept Med, Div Rheumatol, Coll Med, Jacksonville, FL 32209 USA
[2] Univ Toronto, Womens Coll Res Inst, Toronto, ON, Canada
[3] Univ Ottawa, Fac Med, Ottawa, ON, Canada
[4] Oregon Dermatol & Res Ctr, Portland, OR USA
[5] Salt Lake Clin, Salt Lake City, UT USA
关键词
psoriasis; psoriatic arthritis; spondyloarthropathy; QUALITY-OF-LIFE; SEVERE PLAQUE PSORIASIS; SEVERITY INDEX; DISEASE-ACTIVITY; OPEN-LABEL; DERMOSCOPIC FEATURES; JOINT DISEASE; ARTHRITIS; EFFICACY; MODERATE;
D O I
10.3899/jrheum.201471
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. An estimated 40-50% of patients with psoriasis (PsO) have psoriatic nail disease, which is associated with and directly contributes to a greater clinical burden and worse quality of life in these patients. In this review, we examine how recent advances in the use of new diagnostic techniques have led to unproved understanding of the link between nail and musculoskeletal manifestations of psoriatic disease (PsD; e.g., enthesitis, arthritis) and we review targeted therapies for nail PsO (NP). Methods. We performed a literature search to identify which systemic therapies approved for the treatment of PsO and/or psoriatic arthritis (PsA) have been evaluated for the treatment of NP, either as a primary or secondary outcome. A total of 1546 articles were identified on February 18, 2019, and evaluated for relevance. Results. We included findings from 66 articles on systemic therapies for the treatment of NP in PsD. With several scoring systems available for the evaluation of psoriatic nail disease, including varied subtypes and application of the Nail Psoriasis Area Severity Index, there was a high level of methodological heterogeneity across studies. Conclusion. NP is an important predictor of enthesitis, which is associated with the early stages of PsA; therefore, it is important for rheumatologists and dermatologists to accurately diagnose and treat NP to prevent nail damage and potentially delay the onset and progression of joint disease. Further research is needed to address the lack of both standardized NP scoring systems and well-defined treatment guidelines to improve management of PsD.
引用
收藏
页码:1208 / 1220
页数:13
相关论文
共 94 条
[1]   Improvement of quality of life and clinical usefulness of cyclosporin administration in patients with nail psoriasis [J].
Abe, Masatoshi ;
Syuto, Tomoko ;
Yokoyama, Yoko ;
Ishikawa, Osamu .
JOURNAL OF DERMATOLOGY, 2011, 38 (09) :916-918
[2]   Detection of subclinical ultrasound enthesopathy and nail disease in patients at risk of psoriatic arthritis [J].
Acquitter, Marie ;
Misery, Laurent ;
Saraux, Alain ;
Bressollette, Luc ;
Jousse-Joulin, Sandrine .
JOINT BONE SPINE, 2017, 84 (06) :703-707
[3]   Onychomycosis in patients of nail psoriasis on biologic therapy: a randomized, prospective open label study comparing Etanercept, Infliximab and Adalimumab [J].
Al-Mutairi, Nawaf ;
Nour, Tarek ;
Al-Rqobah, Duha .
EXPERT OPINION ON BIOLOGICAL THERAPY, 2013, 13 (05) :625-629
[4]   Vascular Features of Nail Psoriasis Using Dynamic Optical Coherence Tomography [J].
Aldahan, Adam S. ;
Chen, Lucy L. ;
Fertig, Raymond M. ;
Holmes, Jon ;
Shah, Vidhi V. ;
Mlacker, Stephanie ;
Hsu, Vincent M. ;
Nouri, Keyvan ;
Tosti, Antonella .
SKIN APPENDAGE DISORDERS, 2016, 2 (3-4) :102-108
[5]   Nail Psoriasis in Individuals With Psoriasis Vulgaris: A Study of 661 Patients [J].
Armesto, S. ;
Esteve, A. ;
Coto-Segura, P. ;
Drake, M. ;
Galache, C. ;
Martinez-Borra, J. ;
Santos-Juanes, J. .
ACTAS DERMO-SIFILIOGRAFICAS, 2011, 102 (05) :365-372
[6]   Treatments for Nail Psoriasis: A Systematic Review by the GRAPPA Nail Psoriasis Work Group [J].
Armstrong, April W. ;
Tuong, William ;
Love, Thorvardur J. ;
Carneiro, Sueli ;
Grynszpan, Rachel ;
Lee, Steve S. ;
Kavanaugh, Arthur .
JOURNAL OF RHEUMATOLOGY, 2014, 41 (11) :2306-2314
[7]   Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathy than those with normal nails [J].
Ash, Zoe R. ;
Tinazzi, Ilaria ;
Castillo-Gallego, Concepcion ;
Kwok, Chung ;
Wilson, Caroline ;
Goodfield, Mark ;
Gisondi, Paolo ;
Tan, Ai Lyn ;
Marzo-Ortega, Helena ;
Emery, Paul ;
Wakefield, Richard J. ;
McGonagle, Dennis G. ;
Aydin, Sibel Z. .
ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (04) :553-556
[8]   Nail Assessment in Psoriasis and Psoriatic Arthritis (NAPPA): development and validation of a tool for assessment of nail psoriasis outcomes [J].
Augustin, M. ;
Blome, C. ;
Costanzo, A. ;
Dauden, E. ;
Ferrandiz, C. ;
Girolomoni, G. ;
Gniadecki, R. ;
Iversen, L. ;
Menter, A. ;
Michaelis-Wittern, K. ;
Morita, A. ;
Nakagawa, H. ;
Reich, K. .
BRITISH JOURNAL OF DERMATOLOGY, 2014, 170 (03) :591-598
[9]   Nail psoriasis in Germany: epidemiology and burden of disease [J].
Augustin, M. ;
Reich, K. ;
Blome, C. ;
Schaefer, I. ;
Laass, A. ;
Radtke, M. A. .
BRITISH JOURNAL OF DERMATOLOGY, 2010, 163 (03) :580-585
[10]   Ultrasonographic Assessment of Nail in Psoriatic Disease Shows a Link between Onychopathy and Distal Interphalangeal Joint Extensor Tendon Enthesopathy [J].
Aydin, Sibel Zehra ;
Castillo-Gallego, Concepcion ;
Ash, Zoe R. ;
Marzo-Ortega, Helena ;
Emery, Paul ;
Wakefield, Richard J. ;
Wittmann, Miriam ;
McGonagle, Dennis .
DERMATOLOGY, 2012, 225 (03) :231-235