Low sulfide levels and a high degree of cystathionine p-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat

被引：24

作者：

Dziegelewska, Maja ^{[1
]}

Holtze, Susanne ^{[2
]}

Vole, Christiane ^{[3
]}

Wachter, Ulrich ^{[4
]}

Menzel, Uwe ^{[5
]}

Morhart, Michaela ^{[2
]}

Groth, Marco ^{[1
]}

Szafranski, Karol ^{[1
]}

Sahm, Arne ^{[1
]}

Sponholz, Christoph ^{[1
,6
]}

Dammannc, Philip ^{[3
,7
]}

Huse, Klaus ^{[1
]}

Hildebrandt, Thomas ^{[2
]}

Platzer, Matthias ^{[1
]}

机构：

[1] Fritz Lipmann Inst, Leibniz Inst Aging, Genome Anal, Beutenbergstr 11, D-07745 Jena, Germany

[2] Leibniz Inst Zoo & Wildlife Res, Reprod Management, Alfred Kowalke Str 17, D-10315 Berlin, Germany

[3] Univ Duisburg Essen, Dept Gen Zool, Univ Str 2, D-45141 Essen, Germany

[4] Univ Ulm Klinikum, Klin Anasthesiol, Albert Einstein Allee 23, D-89081 Ulm, Germany

[5] Hans Knoell Inst, Leibniz Inst Nat Prod Res & Infect Biol, Beutenbergstr 11a, D-07745 Jena, Germany

[6] Jena Univ Hosp, Dept Anaesthesiol & Intens Care Therapy, Erlanger Allee 101, D-07747 Jena, Germany

[7] Univ Duisburg Essen, Univ Hosp, Cent Anim Lab, Hufelandstr 55, D-45122 Essen, Germany

来源：

REDOX BIOLOGY | 2016年 / 8卷

关键词：

Transsulfuration; Hydrogen sulfide; Methionine; Longevity; Mole-rats; Low methionine diet; BETA-SYNTHASE; HYDROGEN-SULFIDE; LIFE-SPAN; DIETARY RESTRICTION; ZAMBEZIAN REGION; HOMOCYSTEINE; CANCER; LONGEVITY; MICE; BATHYERGIDAE;

D O I：

10.1016/j.redox.2016.01.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet induced longevity models. However, blood sulfide concentration of naturally long-lived species is not known. Here we measured blood sulfide in the long-lived naked mole-rat and five other mammalian species considerably differing in lifespan and found a negative correlation between blood sulfide and maximum longevity residual. In addition, we show that the naked mole-rat cystathionine beta-synthase (CBS), an enzyme whose activity in the liver significantly contributes to systemic sulfide levels, has lower activity in the liver and is activated to a higher degree by S-adenosylmethionine compared to other species. These results add complexity to the understanding of the role of H2S in aging and call for detailed research on naked mole-rat transsulfuration. (C) 2016 The Authors. Published by Elsevier B.V.

引用

页码：192 / 198

页数：7

共 39 条

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