HPV-16 E5 down-regulates expression of surface HLA class I by CD8 T cells

被引：104

作者：

Campo, M. S. ^{[1
]}

Graham, S. V. ^{[2
]}

Cortese, M. S. ^{[1
]}

Ashrafi, G. H. ^{[1
]}

Araibi, E. H. ^{[1
]}

Dornan, E. S. ^{[1
]}

Miners, K. ^{[3
]}

Nunes, C. ^{[3
]}

Man, S. ^{[3
]}

机构：

[1] Univ Glasgow, Inst Comparat Med, Div Pathol Sci, Glasgow G61 1QH, Lanark, Scotland

[2] Univ Glasgow, Div Infect & Immun, Fac Biomed & Life Sci, Glasgow G61 1QH, Lanark, Scotland

[3] Cardiff Univ, Dept Infect Immun & Biochem, Cardiff CF14 4XN, S Glam, Wales

来源：

VIROLOGY | 2010年 / 407卷 / 01期

关键词：

HPV-16; E5; W12; HLA down-regulation; CD8 T cells; Immuno evasion; HUMAN-PAPILLOMAVIRUS TYPE-16; MHC CLASS-I; 1ST HYDROPHOBIC DOMAIN; ONCOPROTEIN; HUMAN-PAPILLOMAVIRUS-16; INFILTRATION; LYMPHOCYTES; INTEGRATION; REGRESSION; EVASION;

D O I：

10.1016/j.virol.2010.07.044

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HPV-16 is the major causes of cervical cancer. Persistence of infection is a necessary event for progression of the infection to cancer. Among other factors, virus persistence is due the viral proteins fighting the immune response. HPV-16 E5 down-regulates MHC/HLA class I. which is much reduced on the cell surface and accumulates in the Golgi apparatus in cells expressing E5. This effect is observed also in W12 cells, which mimic early cervical intraepithelial progression to cervical cancer. The functional effect of MHC I down-regulation on human CD8 T cells is not known, because of the need for HLA-matched, HPV-specific T cells that recognise E5 expressing-cells. Here we employ a heterologous cell/MHC I system which uses mouse cells expressing both E5 and HLA-A2, and A2-restricted CTLs: we show that the E5-induced reduction of HLA-A2 has a functional impact by reducing recognition of E5 expressing cells by HPV specific CD8+ T cells. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：137 / 142

页数：6

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