Copper(II)-Catalyzed C-N Coupling of Aryl Halides and N-Nucleophiles Promoted by Quebrachitol or Diethylene Glycol

被引：8

作者：

Du, Fangyu ^{[1
]}

Zhou, Qifan ^{[1
]}

Fu, Yang ^{[1
]}

Chen, Yuanguang ^{[1
]}

Wu, Ying ^{[2
]}

Chen, Guoliang ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China

[2] Yunnan Inst Trop Crops, Jinghong 666100, Peoples R China

来源：

SYNLETT | 2019年 / 30卷 / 19期

关键词：

N-arylation; quebrachitol; diethylene glycol; Cu(OAc)(2); Ullman coupling; AROMATIC-SUBSTITUTION; (HETERO)ARYL HALIDES; COPPER; LIGANDS; TAMIBAROTENE; AMIDATION; AMINATION; TACRINE; ANALOGS;

D O I：

10.1055/s-0039-1690707

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report the natural ligand quebrachitol (QCT) as a promoter for a Cu(II) catalyst, which is highly effective for N-arylation of various amines and related aryl halides. A series of diarylamine derivatives were obtained in high yields by using diethylene glycol (DEG) as both ligand and solvent. The C-N coupling reactions proceed under mild conditions and exhibit good functional group tolerance.

引用

页码：2161 / 2168

页数：8

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