Copper(II)-Catalyzed C-N Coupling of Aryl Halides and N-Nucleophiles Promoted by Quebrachitol or Diethylene Glycol

被引：8
|
作者：
Du, Fangyu [1 ]
Zhou, Qifan [1 ]
Fu, Yang [1 ]
Chen, Yuanguang [1 ]
Wu, Ying [2 ]
Chen, Guoliang [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China
[2] Yunnan Inst Trop Crops, Jinghong 666100, Peoples R China
来源：
SYNLETT | 2019年 / 30卷 / 19期
关键词：
N-arylation; quebrachitol; diethylene glycol; Cu(OAc)(2); Ullman coupling; AROMATIC-SUBSTITUTION; (HETERO)ARYL HALIDES; COPPER; LIGANDS; TAMIBAROTENE; AMIDATION; AMINATION; TACRINE; ANALOGS;
D O I：
10.1055/s-0039-1690707
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report the natural ligand quebrachitol (QCT) as a promoter for a Cu(II) catalyst, which is highly effective for N-arylation of various amines and related aryl halides. A series of diarylamine derivatives were obtained in high yields by using diethylene glycol (DEG) as both ligand and solvent. The C-N coupling reactions proceed under mild conditions and exhibit good functional group tolerance.
引用
收藏
页码：2161 / 2168
页数：8
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